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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1994-3-17
|
| pubmed:abstractText |
A sample of 219 primary stomach cancers, 143 advanced cancers and 76 early cancers were examined for mucin histochemical staining (the paradoxical concanavalin A method, the galactose oxidase-Schiff [GOS] reaction, and the sialidase-GOS reaction) and immunohistochemical reactivity (pepsinogen [Pg] I, Pg II, SH-9 and TKH-2). Gastric cancer cells were clearly classified according to mucin histochemistry into a gastric type, including mucus neck cell, pyloric gland cell and surface mucus cell types, and an intestinal type, including goblet-cell, and intestinal absorptive cell types. TKH-2 monoclonal antibody, which recognizes the mucin-associated sialosyl-Tn antigen, reacted with the mucin of goblet cells in both the normal small intestine and in the intestinal metaplasia of the stomach. Sixty-five of 106 (61%) differentiated adenocarcinomas and 76 of 113 (67%) undifferentiated adenocarcinomas had over 10% of their cancer cells positive for TKH-2. The TKH-2-positive cancers were primarily classified as a goblet-cell type by mucin-histochemical staining and the other immunohistochemical staining methods. Therefore, it is concluded that sialosyl-Tn is an excellent marker of small intestinal mucins and is indicative of a small intestinal type of differentiation in two-thirds of gastric cancers.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Tumor-Associated...,
http://linkedlifedata.com/resource/pubmed/chemical/Mucins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/sialosyl-Tn antigen
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0001-6632
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
43
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
646-53
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8310825-Adult,
pubmed-meshheading:8310825-Aged,
pubmed-meshheading:8310825-Aged, 80 and over,
pubmed-meshheading:8310825-Antibodies, Monoclonal,
pubmed-meshheading:8310825-Antigens, Tumor-Associated, Carbohydrate,
pubmed-meshheading:8310825-Duodenum,
pubmed-meshheading:8310825-Female,
pubmed-meshheading:8310825-Gastric Mucosa,
pubmed-meshheading:8310825-Humans,
pubmed-meshheading:8310825-Immunoenzyme Techniques,
pubmed-meshheading:8310825-Intestinal Mucosa,
pubmed-meshheading:8310825-Intestinal Neoplasms,
pubmed-meshheading:8310825-Male,
pubmed-meshheading:8310825-Metaplasia,
pubmed-meshheading:8310825-Middle Aged,
pubmed-meshheading:8310825-Mucins,
pubmed-meshheading:8310825-Phenotype,
pubmed-meshheading:8310825-Reference Values,
pubmed-meshheading:8310825-Stomach Neoplasms,
pubmed-meshheading:8310825-Tumor Markers, Biological
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Expression of sialosyl-Tn in intestinal type cancer cells of human gastric cancers.
|
| pubmed:affiliation |
Laboratory of Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan.
|
| pubmed:publicationType |
Journal Article
|