| pubmed-article:8272871 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8272871 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:8272871 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:8272871 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:8272871 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8272871 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:8272871 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:8272871 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:8272871 | pubmed:issue | 5143 | lld:pubmed |
| pubmed-article:8272871 | pubmed:dateCreated | 1994-2-2 | lld:pubmed |
| pubmed-article:8272871 | pubmed:abstractText | Transforming growth factor beta (TGF-beta) is a multifunctional factor that regulates many aspects of cellular functions. TGF-beta signals through a heteromeric complex of the type I and type II TGF-beta receptors. However, the molecular mechanism of signal transduction by this receptor complex remains unresolved. The type II receptor belongs to a transmembrane receptor serine-threonine kinase family. A new member of this receptor family (R4) was identified and shown to be a functional TGF-beta type I receptor on the basis of its ability to restore a TGF-beta-induced gene response in mutant cell lines lacking endogenous type I receptor. Both ligand binding and signaling of the R4 protein were dependent on the presence of a functional type II receptor. The type I receptor has an intrinsic serine-threonine kinase activity, which was essential for signal transduction. | lld:pubmed |
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| pubmed-article:8272871 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8272871 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8272871 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8272871 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8272871 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8272871 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:8272871 | pubmed:author | pubmed-author:DonahoeP KPK | lld:pubmed |
| pubmed-article:8272871 | pubmed:author | pubmed-author:WangX FXF | lld:pubmed |
| pubmed-article:8272871 | pubmed:author | pubmed-author:WangTT | lld:pubmed |
| pubmed-article:8272871 | pubmed:author | pubmed-author:JustWW | lld:pubmed |
| pubmed-article:8272871 | pubmed:author | pubmed-author:ShahPP | lld:pubmed |
| pubmed-article:8272871 | pubmed:author | pubmed-author:YinglingJ MJM | lld:pubmed |
| pubmed-article:8272871 | pubmed:author | pubmed-author:BassingC HCH | lld:pubmed |
| pubmed-article:8272871 | pubmed:author | pubmed-author:HeW WWW | lld:pubmed |
| pubmed-article:8272871 | pubmed:author | pubmed-author:GustafsonM... | lld:pubmed |
| pubmed-article:8272871 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8272871 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:8272871 | pubmed:volume | 263 | lld:pubmed |
| pubmed-article:8272871 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8272871 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8272871 | pubmed:pagination | 87-9 | lld:pubmed |
| pubmed-article:8272871 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:8272871 | pubmed:meshHeading | pubmed-meshheading:8272871-... | lld:pubmed |
| pubmed-article:8272871 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8272871 | pubmed:articleTitle | A transforming growth factor beta type I receptor that signals to activate gene expression. | lld:pubmed |
| pubmed-article:8272871 | pubmed:affiliation | Department of Pharmacology, Duke University Medical Center, Durham, NC 27710. | lld:pubmed |
| pubmed-article:8272871 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8272871 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8272871 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:8272871 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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