Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1993-12-16
|
| pubmed:abstractText |
The effects of the potassium channel activators (KCA) levcromakalim and RP52891 on NANCe nerve-mediated changes in pulmonary dynamics were investigated in the anaesthetized guinea-pig, using a newly-developed respiratory dynamics computer. Levcromakalim (0.025-0.2 mg/kg i.v.) and RP52891 (0.05-0.5 mg/kg i.v.) caused dose-dependent inhibition of NANCe nerve-mediated increases in airways resistance (RAW) and decreases in dynamic compliance (Cdyn). These effects of the KCAs persisted for at least 1 h. Unlike NANCe nerve-mediated responses, equivalent challenges with exogenously-administered substance P (SP; 10-25 micrograms/kg i.v.) and neurokinin A (NKA; 0.5-2.0 micrograms/kg i.v.) tended to produce progressively increasing responses but this effect was not statistically significant. Levcromakalim (0.2 mg/kg i.v.) and RP52891 (0.5 mg/kg i.v.) did not significantly decrease responses to exogenously-administered SP, although NKA-induced bronchoconstriction was attenuated. Glibenclamide (25 mg/kg i.v.) partially reversed the NANCe-inhibitory effects of levcromakalim (0.1 mg/kg i.v.) and RP52891 (0.25 mg/kg i.v.) and fully reversed their hypotensive effects. We have shown that levcromakalim and RP52891 inhibit bronchoconstrictor responses to NANCe nerve stimulation. This involves the opening of a glibenclamide-sensitive K(+)-channel and may represent effects at a pre-junctional site on NANCe neurones to reduce transmitter release.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzopyrans,
http://linkedlifedata.com/resource/pubmed/chemical/Bronchodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cromakalim,
http://linkedlifedata.com/resource/pubmed/chemical/Picolines,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrans,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles,
http://linkedlifedata.com/resource/pubmed/chemical/aprikalim
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0952-0600
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
6
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
201-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8219574-Airway Resistance,
pubmed-meshheading:8219574-Animals,
pubmed-meshheading:8219574-Autonomic Nervous System,
pubmed-meshheading:8219574-Benzopyrans,
pubmed-meshheading:8219574-Bronchoconstriction,
pubmed-meshheading:8219574-Bronchodilator Agents,
pubmed-meshheading:8219574-Cromakalim,
pubmed-meshheading:8219574-Dose-Response Relationship, Drug,
pubmed-meshheading:8219574-Electric Stimulation,
pubmed-meshheading:8219574-Guinea Pigs,
pubmed-meshheading:8219574-Lung,
pubmed-meshheading:8219574-Male,
pubmed-meshheading:8219574-Picolines,
pubmed-meshheading:8219574-Potassium Channels,
pubmed-meshheading:8219574-Pyrans,
pubmed-meshheading:8219574-Pyrroles,
pubmed-meshheading:8219574-Respiration,
pubmed-meshheading:8219574-Respiratory Function Tests,
pubmed-meshheading:8219574-Vagus Nerve
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Effects of levcromakalim and RP52891 on NANCe nerve-mediated changes in pulmonary dynamics evoked by vagal stimulation in the guinea-pig.
|
| pubmed:affiliation |
SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|