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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5 Pt 2
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pubmed:dateCreated |
1994-7-5
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pubmed:abstractText |
Nitric oxide (NO) is a tonically produced vasodilator that maintains blood pressure (BP) in the normal animal. In these studies, we produced chronic NO blockade by oral administration of the NO synthesis inhibitor nitro-L-arginine methyl ester (L-NAME), which produced sustained hypertension and increased renal vascular resistance (RVR) in conscious rats. Acute blockade of the angiotensin II type 1 (AT1) receptor with losartan had little effect on BP and RVR in either chronically NO-blocked or normal conscious rats. Acute blockade of the alpha 1-adrenoceptor with prazosin produced moderate similar falls in BP in both chronically NO-blocked and normal rats. The combination of AT1 and alpha 1-adrenoceptor blockade was profoundly antihypertensive and was particularly effective in lowering BP in chronically NO-blocked rats where the hypertension was obliterated. In contrast, the increased RVR persisted in chronically NO-blocked rats receiving combined acute AT1 and alpha 1-adrenoceptor blockade. These observations indicate that, in the sustained phase of chronic NO blockade, the hypertension is largely due to the combined activities of alpha 1-adrenoceptor and AT1 stimulation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin Receptor Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Arginine,
http://linkedlifedata.com/resource/pubmed/chemical/Biphenyl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Losartan,
http://linkedlifedata.com/resource/pubmed/chemical/NG-Nitroarginine Methyl Ester,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Prazosin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Angiotensin,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrazoles
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0002-9513
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
266
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R1470-6
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8203622-Administration, Oral,
pubmed-meshheading:8203622-Angiotensin II,
pubmed-meshheading:8203622-Angiotensin Receptor Antagonists,
pubmed-meshheading:8203622-Animals,
pubmed-meshheading:8203622-Arginine,
pubmed-meshheading:8203622-Biphenyl Compounds,
pubmed-meshheading:8203622-Blood Pressure,
pubmed-meshheading:8203622-Glomerular Filtration Rate,
pubmed-meshheading:8203622-Hematocrit,
pubmed-meshheading:8203622-Hypertension,
pubmed-meshheading:8203622-Imidazoles,
pubmed-meshheading:8203622-Kidney,
pubmed-meshheading:8203622-Losartan,
pubmed-meshheading:8203622-Male,
pubmed-meshheading:8203622-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:8203622-Nitric Oxide,
pubmed-meshheading:8203622-Prazosin,
pubmed-meshheading:8203622-Rats,
pubmed-meshheading:8203622-Rats, Sprague-Dawley,
pubmed-meshheading:8203622-Receptors, Adrenergic, alpha-1,
pubmed-meshheading:8203622-Receptors, Angiotensin,
pubmed-meshheading:8203622-Reference Values,
pubmed-meshheading:8203622-Regional Blood Flow,
pubmed-meshheading:8203622-Renal Circulation,
pubmed-meshheading:8203622-Tetrazoles,
pubmed-meshheading:8203622-Vascular Resistance
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pubmed:year |
1994
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pubmed:articleTitle |
Angiotensin II and alpha 1-adrenergic tone in chronic nitric oxide blockade-induced hypertension.
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pubmed:affiliation |
Department of Physiology, West Virginia University, Morgantown 26506-9229.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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