| pubmed-article:8198931 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8198931 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8198931 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:8198931 | lifeskim:mentions | umls-concept:C0026030 | lld:lifeskim |
| pubmed-article:8198931 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:8198931 | lifeskim:mentions | umls-concept:C0020934 | lld:lifeskim |
| pubmed-article:8198931 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:8198931 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:8198931 | pubmed:dateCreated | 1994-7-7 | lld:pubmed |
| pubmed-article:8198931 | pubmed:abstractText | 1. The metabolism of imipramine (N-demethylation and 2-hydroxylation) was studied in relation to the activity of S-mephenytoin 4'-hydroxylase in human liver microsomes. 2. Eadie-Hofstee plots for the formation of despiramine and 2-hydroxyimipramine were biphasic, suggesting that at least two enzymes are involved in both the N-demethylation and 2-hydroxylation of imipramine by human liver microsomes. 3. The respective mean (+/- s.d.) kinetic parameters for the N-demethylation and 2-hydroxylation of imipramine derived from a two-enzyme kinetic analysis were: Km1 = 1.1 +/- 0.4 and 1.6 +/- 0.6 microM, Vmax1 = 0.11 +/- 0.03 and 0.15 +/- 0.07 nmol mg-1 min-1, and Vmax1/Km1 = 0.10 +/- 0.02 and 0.09 +/- 0.04 ml mg-1 min-1; Km2 = 214 +/- 84 and 257 +/- 148 microM, Vmax2 = 2.22 +/- 0.69 and 0.53 +/- 0.15 nmol mg-1 min-1, and Vmax2/Km2 = 0.011 +/- 0.001 and 0.003 +/- 0.002 ml mg-1 min-1. 4. With regard to imipramine N-demethylation and 2-hydroxylation at 2 microM (representing high-affinity reactions) and at 400 microM (representing low-affinity reactions), only N-demethylation at 2 microM showed a close correlation with the 4'-hydroxylation of S-mephenytoin (rs = 0.952, P < 0.01; n = 10 livers). 5. Concentrations up to 250 microM S-mephenytoin inhibited the N-demethylation of imipramine (2 microM), but no further inhibition was observed using concentrations from 250 to 750 microM. 6. Imipramine inhibited S-mephenytoin 4'-hydroxylation competitively with a Ki value of 12.5 microM.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
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| pubmed-article:8198931 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8198931 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8198931 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8198931 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8198931 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8198931 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:8198931 | pubmed:issn | 0306-5251 | lld:pubmed |
| pubmed-article:8198931 | pubmed:author | pubmed-author:HayashiMM | lld:pubmed |
| pubmed-article:8198931 | pubmed:author | pubmed-author:ChibaKK | lld:pubmed |
| pubmed-article:8198931 | pubmed:author | pubmed-author:IshizakiTT | lld:pubmed |
| pubmed-article:8198931 | pubmed:author | pubmed-author:TaniMM | lld:pubmed |
| pubmed-article:8198931 | pubmed:author | pubmed-author:SaitohAA | lld:pubmed |
| pubmed-article:8198931 | pubmed:author | pubmed-author:KoyamaEE | lld:pubmed |
| pubmed-article:8198931 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8198931 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:8198931 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8198931 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8198931 | pubmed:pagination | 237-42 | lld:pubmed |
| pubmed-article:8198931 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8198931 | pubmed:meshHeading | pubmed-meshheading:8198931-... | lld:pubmed |
| pubmed-article:8198931 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8198931 | pubmed:articleTitle | The role of S-mephenytoin 4'-hydroxylase in imipramine metabolism by human liver microsomes: a two-enzyme kinetic analysis of N-demethylation and 2-hydroxylation. | lld:pubmed |
| pubmed-article:8198931 | pubmed:affiliation | Division of Clinical Pharmacology, National Medical Center, Tokyo, Japan. | lld:pubmed |
| pubmed-article:8198931 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8198931 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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