| pubmed-article:8142599 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8142599 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:8142599 | lifeskim:mentions | umls-concept:C0543467 | lld:lifeskim |
| pubmed-article:8142599 | lifeskim:mentions | umls-concept:C0000726 | lld:lifeskim |
| pubmed-article:8142599 | lifeskim:mentions | umls-concept:C0003483 | lld:lifeskim |
| pubmed-article:8142599 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:8142599 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:8142599 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:8142599 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8142599 | pubmed:dateCreated | 1994-5-5 | lld:pubmed |
| pubmed-article:8142599 | pubmed:abstractText | During shock or multiple organ dysfunction syndrome, translocation of bacteria and/or lipopolysaccharide (LPS) from the ischaemic gut might occur and could explain the excess of cytokine production detectable in plasma. To test this hypothesis, we studied a model of mild gut ischaemia due to bowel manipulation and aortic clamping in patients undergoing abdominal aortic surgery (n = 14). Per-operative levels of LPS and cytokines were measured before clamping and after reperfusion, and compared in systemic and portal blood. Systemic levels of LPS and cytokines were measured in a control group of patients undergoing internal carotid surgery (n = 7). Portal LPS was detectable (i.e., > 12 pg/ml) in 36% of the patients undergoing aortic surgery after bowel manipulation, and in 71% after clamp release. Similar levels of LPS were observed in portal and systemic blood after clamp release. Circulating tumour necrosis factor alpha (TNF-alpha) was observed in all patients undergoing aortic surgery. Levels of portal TNF-alpha were higher than those in systemic blood after bowel manipulation as well as after reperfusion (P = 0.02 and 0.007, respectively). LPS was never detected in control patients and TNF-alpha was detectable in only two out of seven patients. Mean levels of IL-6 were similar in the two groups, with a peak on the day following surgery, confirming that circulating IL-6 is associated with any surgical procedures. Our data indicate that bowel manipulation, aortic clamping and reperfusion lead to similar levels of portal and systemic circulating LPS.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:8142599 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8142599 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8142599 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8142599 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8142599 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8142599 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8142599 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8142599 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:8142599 | pubmed:issn | 1043-4666 | lld:pubmed |
| pubmed-article:8142599 | pubmed:author | pubmed-author:CormierJ MJM | lld:pubmed |
| pubmed-article:8142599 | pubmed:author | pubmed-author:CarletJJ | lld:pubmed |
| pubmed-article:8142599 | pubmed:author | pubmed-author:CavaillonJ... | lld:pubmed |
| pubmed-article:8142599 | pubmed:author | pubmed-author:LaurianCC | lld:pubmed |
| pubmed-article:8142599 | pubmed:author | pubmed-author:FittingCC | lld:pubmed |
| pubmed-article:8142599 | pubmed:author | pubmed-author:FarkasJ CJC | lld:pubmed |
| pubmed-article:8142599 | pubmed:author | pubmed-author:CabièAA | lld:pubmed |
| pubmed-article:8142599 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8142599 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:8142599 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8142599 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8142599 | pubmed:pagination | 448-53 | lld:pubmed |
| pubmed-article:8142599 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8142599 | pubmed:meshHeading | pubmed-meshheading:8142599-... | lld:pubmed |
| pubmed-article:8142599 | pubmed:meshHeading | pubmed-meshheading:8142599-... | lld:pubmed |
| pubmed-article:8142599 | pubmed:meshHeading | pubmed-meshheading:8142599-... | lld:pubmed |
| pubmed-article:8142599 | pubmed:meshHeading | pubmed-meshheading:8142599-... | lld:pubmed |
| pubmed-article:8142599 | pubmed:meshHeading | pubmed-meshheading:8142599-... | lld:pubmed |
| pubmed-article:8142599 | pubmed:meshHeading | pubmed-meshheading:8142599-... | lld:pubmed |
| pubmed-article:8142599 | pubmed:meshHeading | pubmed-meshheading:8142599-... | lld:pubmed |
| pubmed-article:8142599 | pubmed:meshHeading | pubmed-meshheading:8142599-... | lld:pubmed |
| pubmed-article:8142599 | pubmed:meshHeading | pubmed-meshheading:8142599-... | lld:pubmed |
| pubmed-article:8142599 | pubmed:meshHeading | pubmed-meshheading:8142599-... | lld:pubmed |
| pubmed-article:8142599 | pubmed:meshHeading | pubmed-meshheading:8142599-... | lld:pubmed |
| pubmed-article:8142599 | pubmed:meshHeading | pubmed-meshheading:8142599-... | lld:pubmed |
| pubmed-article:8142599 | pubmed:meshHeading | pubmed-meshheading:8142599-... | lld:pubmed |
| pubmed-article:8142599 | pubmed:meshHeading | pubmed-meshheading:8142599-... | lld:pubmed |
| pubmed-article:8142599 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8142599 | pubmed:articleTitle | High levels of portal TNF-alpha during abdominal aortic surgery in man. | lld:pubmed |
| pubmed-article:8142599 | pubmed:affiliation | Unité d'Immuno-Allergie, Institut Pasteur, Paris, France. | lld:pubmed |
| pubmed-article:8142599 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8142599 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8142599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8142599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8142599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:8142599 | lld:pubmed |
