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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1994-5-5
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pubmed:abstractText |
During shock or multiple organ dysfunction syndrome, translocation of bacteria and/or lipopolysaccharide (LPS) from the ischaemic gut might occur and could explain the excess of cytokine production detectable in plasma. To test this hypothesis, we studied a model of mild gut ischaemia due to bowel manipulation and aortic clamping in patients undergoing abdominal aortic surgery (n = 14). Per-operative levels of LPS and cytokines were measured before clamping and after reperfusion, and compared in systemic and portal blood. Systemic levels of LPS and cytokines were measured in a control group of patients undergoing internal carotid surgery (n = 7). Portal LPS was detectable (i.e., > 12 pg/ml) in 36% of the patients undergoing aortic surgery after bowel manipulation, and in 71% after clamp release. Similar levels of LPS were observed in portal and systemic blood after clamp release. Circulating tumour necrosis factor alpha (TNF-alpha) was observed in all patients undergoing aortic surgery. Levels of portal TNF-alpha were higher than those in systemic blood after bowel manipulation as well as after reperfusion (P = 0.02 and 0.007, respectively). LPS was never detected in control patients and TNF-alpha was detectable in only two out of seven patients. Mean levels of IL-6 were similar in the two groups, with a peak on the day following surgery, confirming that circulating IL-6 is associated with any surgical procedures. Our data indicate that bowel manipulation, aortic clamping and reperfusion lead to similar levels of portal and systemic circulating LPS.(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1043-4666
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
448-53
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8142599-Aged,
pubmed-meshheading:8142599-Aorta, Abdominal,
pubmed-meshheading:8142599-Digestive System,
pubmed-meshheading:8142599-Follow-Up Studies,
pubmed-meshheading:8142599-Humans,
pubmed-meshheading:8142599-Interleukin-6,
pubmed-meshheading:8142599-Intraoperative Complications,
pubmed-meshheading:8142599-Ischemia,
pubmed-meshheading:8142599-Lipopolysaccharides,
pubmed-meshheading:8142599-Longitudinal Studies,
pubmed-meshheading:8142599-Male,
pubmed-meshheading:8142599-Middle Aged,
pubmed-meshheading:8142599-Portal System,
pubmed-meshheading:8142599-Tumor Necrosis Factor-alpha
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pubmed:year |
1993
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pubmed:articleTitle |
High levels of portal TNF-alpha during abdominal aortic surgery in man.
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pubmed:affiliation |
Unité d'Immuno-Allergie, Institut Pasteur, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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