Linked Life Data

8137864

Source:http://linkedlifedata.com/resource/pubmed/id/8137864

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-4-28
pubmed:abstractText
The selectivity of N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]-ethylamine monohydrochloride (NE-100) for sigma 1 and sigma 2 binding sites was studied by means of binding of [3H](+)-pentazocine and [3H]1,3-di-o-tolylguanidine ([3H]DTG) in guinea pig brain. NE-100 inhibited [3H](+)-pentazocine binding to sigma 1 binding sites potently with an IC50 value of 1.54 +/- 0.26 nM while it had a weak effect on [3H]DTG binding to sigma 2 binding sites. The inhibitory effect of NE-100 on [3H](+)-pentazocine was 55 times more potent than that on [3H]DTG binding. These results suggest that NE-100 is a potent and selective ligand for sigma 1 binding sites.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
251
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R1-2
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
NE-100, a novel potent sigma ligand, preferentially binds to sigma 1 binding sites in guinea pig brain.
pubmed:affiliation
Department of Pharmacology, Taisho Pharmaceutical Co. Ltd., Saitama, Japan.
pubmed:publicationType
Journal Article, In Vitro