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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
1994-4-6
|
| pubmed:abstractText |
The effects of dietary vitamin E levels on tissue alpha-tocopherol (alpha-T) concentrations in different parts of the nervous system are largely unknown. Therefore, we measured the alpha-T contents of nervous and other tissues obtained from beagle dogs fed for two years a vitamin E-deficient diet (-E, 0.05 +/- 0.02 mg vitamin E/kg diet, n = 2), a vitamin E-supplemented diet (+E, 114 +/- 14 mg/kg, n = 2), or a standard chow diet (En, 74 +/- 6 mg/kg, n = 3). Brain regions and spinal cords of +E dogs contained about double the alpha-T concentrations of En dogs, and about 10-fold those of -E dogs. The various brain regions of -E dogs, compared with En dogs, retained 12-18% of the alpha-T concentrations, with the exception of the caudal colliculus, which retained 48%. Peripheral nerve alpha-T concentrations in +E dogs (67 ng/mg wet weight) were nearly 5-fold higher than in En dogs (13.4 +/- 5.9 ng/mg) and 80-fold higher than in -E dogs (0.8 ng/mg). Within each dietary group, the lowest alpha-T concentrations in the central nervous system (CNS) were in the spinal cord. Peripheral nerves were the most susceptible to vitamin E repletion or depletion: in +E dogs, nerves contained higher concentrations of alpha-T than most brain regions; in En dogs, they contained similar concentrations; but in -E dogs, they contained less alpha-T than most brain regions. Muscles and other tissues of -E dogs retained from 1 to 10% of En values.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0024-4201
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1101-5
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:8121252-Animals,
pubmed-meshheading:8121252-Brain,
pubmed-meshheading:8121252-Central Nervous System,
pubmed-meshheading:8121252-Diet,
pubmed-meshheading:8121252-Dogs,
pubmed-meshheading:8121252-Female,
pubmed-meshheading:8121252-Male,
pubmed-meshheading:8121252-Muscles,
pubmed-meshheading:8121252-Peripheral Nerves,
pubmed-meshheading:8121252-Spinal Cord,
pubmed-meshheading:8121252-Vitamin E,
pubmed-meshheading:8121252-Vitamin E Deficiency
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Alpha-tocopherol concentrations of the nervous system and selected tissues of adult dogs fed three levels of vitamin E.
|
| pubmed:affiliation |
Scott-Ritchey Research Center, College of Veterinary Medicine, Auburn University, Alabama 36849.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|