Linked Life Data

8083498

Source:http://linkedlifedata.com/resource/pubmed/id/8083498

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1994-10-13
pubmed:abstractText
The administration of 17-beta estradiol to human, and all the animals species tested, results in blood volume expansion. This effect has been postulated to be mediated through an increase in the circulating levels of aldosterone. We infused 17-beta estradiol (30 micrograms/kg/day) into 5 chronically-castrated ewes over a 3-week period, and determined the plasma concentrations of 17-beta estradiol, PRA, and aldosterone at weekly intervals. By the end of the third week, 17-beta estradiol plasma concentration had increased 150-fold, while PRA increased 2-fold; aldosterone decreased 40% from baseline values. Thus, during a period in which we have previously observed blood volume expansion, there was a dissociation between the levels of 17-beta estradiol and aldosterone. These findings question the theory that the estradiol-mediated blood volume increase observed during pregnancy is secondary to an increase in the circulating aldosterone levels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0141-9846
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
213-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Estradiol effects on plasma renin activity and aldosterone in chronically catheterized castrated sheep.
pubmed:affiliation
Division of Perinatal Biology, Loma Linda University, California 92350.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't