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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
1994-8-22
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pubmed:databankReference |
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pubmed:abstractText |
A cDNA corresponding to a thiol-specific antioxidant enzyme (TSA) was isolated from a rat brain cDNA library with the use of antibodies to bovine TSA. The cDNA clone encoded an open reading frame capable of encoding a 198-residue polypeptide. The rat and yeast TSA proteins show significant sequence homology to the 21-kDa component (AhpC) of Salmonella typhimurium alkyl hydroperoxide reductase, and we have found that AhpC exhibits TSA activity. AhpC and TSA define a family of > 25 different proteins present in organisms from all kingdoms. The similarity among the family members extends over the entire sequence and ranges between 23% and 98% identity. A majority of the members of the AhpC/TSA family contain two conserved cysteines. At least eight of the genes encoding AhpC/TSA-like polypeptides are found in proximity to genes encoding other oxidoreductase activities, and the expression of several of the homologs has been correlated with pathogenicity. We suggest that the AhpC/TSA family represents a widely distributed class of antioxidant enzymes. We also report that a second family of proteins, defined by the 57-kDa component (AhpF) of alkyl hydroperoxide reductase and by thioredoxin reductase, has expanded to include six additional members.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-1345164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-1371765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-1377965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-1404382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-1637309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-1917890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-1987145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-2016588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-2047873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-2122808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-2191951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-2201027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-2227455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-2314283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-2373154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-2439888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-2501302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-2583515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-2643600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-2649484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-2668950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-2760020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-2847922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-2891705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-2895105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-3288628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-3321061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-7688300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-8041739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-8123050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-8294408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-8344960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-8360158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-8386507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-8494361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8041738-8496166
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7017-21
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8041738-Amino Acid Sequence,
pubmed-meshheading:8041738-Animals,
pubmed-meshheading:8041738-Antioxidants,
pubmed-meshheading:8041738-Base Sequence,
pubmed-meshheading:8041738-Brain,
pubmed-meshheading:8041738-Cattle,
pubmed-meshheading:8041738-Cloning, Molecular,
pubmed-meshheading:8041738-DNA,
pubmed-meshheading:8041738-Humans,
pubmed-meshheading:8041738-Molecular Sequence Data,
pubmed-meshheading:8041738-Oxidoreductases,
pubmed-meshheading:8041738-Peroxidases,
pubmed-meshheading:8041738-Peroxiredoxins,
pubmed-meshheading:8041738-Proteins,
pubmed-meshheading:8041738-Rats,
pubmed-meshheading:8041738-Sequence Homology, Amino Acid
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pubmed:year |
1994
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pubmed:articleTitle |
Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes.
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pubmed:affiliation |
Laboratory of Biochemistry, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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