Linked Life Data

8010068

Source:http://linkedlifedata.com/resource/pubmed/id/8010068

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1994-7-20
pubmed:abstractText
In anesthetized dogs intraduodenal administration of m-nifedipine (m-Nif) 0.4 mg.kg-1, coronary flow increased from 708 +/- 72 to 880 +/- 150 ml.min-1.kg-1 (+24%) at 5 min, to 1976 +/- 350 ml.min-1.kg-1 (+179%) at 30 min, and to 998 +/- 250 ml.min-1.kg-1 (+41%) at 4 h. At the dose of nifedipine (Nif), coronary flow increased from 778 +/- 91 to 1080 +/- 90 ml.min-1.kg-1 (+39%) at 3 min and to 1836 +/- 280 ml.min-1.kg-1 (+136%) at 90 min. m-Nif was more 43% potent than Nif and the duration of action of m-Nif was longer. m-Nif reduced heart rate by -39%, while Nif reduced only -11%. m-Nif increased coronary sinus O2 content and reduced MVO2, and no difference was seen between these 2 drugs. However, the rate of CO2 production with m-Nif was reduced to a greater degree than that of Nif. The results indicated that m-Nif was more beneficial in alleviating myocardial ischemia than that of Nif.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0253-9756
pubmed:author
pubmed:issnType
Print
pubmed:volume
14 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S25-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
[Effects of m-nifedipine and nifedipine given intraduodenally on coronary flow, myocardial oxygen, and carbon dioxide metabolism in dogs].
pubmed:affiliation
Department of Cardiovascular Pharmacology, Nanjing Medical College, China.
pubmed:publicationType
Journal Article, Comparative Study, English Abstract, Research Support, Non-U.S. Gov't