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rdf:type |
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lifeskim:mentions |
umls-concept:C0025252,
umls-concept:C0032155,
umls-concept:C0085358,
umls-concept:C0205197,
umls-concept:C0376518,
umls-concept:C0562648,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1511636,
umls-concept:C1522642,
umls-concept:C1545588,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
7
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pubmed:dateCreated |
1994-7-20
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pubmed:abstractText |
BALB/c mice immunized with irradiated Plasmodium yoelii sporozoites produce antibodies and cytotoxic T lymphocytes against the circumsporozoite protein and against a 140-kDa protein, sporozoite surface protein 2 (PySSP2). Approximately 50% of mice immunized with P815 cells transfected with the gene encoding PySSP2 are protected against malaria, and this protection is reversed by in vivo depletion of CD8+ T cells. To determine if CD8+ T cells against PySSP2 are adequate to protect against malaria in the absence of other malaria-specific immune responses, we produced three CD8+ T-cell clones by stimulating spleen cells from mice immunized with irradiated P. yoelii sporozoites with a mitomycin-treated P815 cell clone transfected with the PySSP2 gene. Adoptive transfer of clone TSLB7 protected 100% of mice against P. yoelii. The second clone protected 58% of mice, and the third clone provided no protection. Clone TSLB7 protected even when administered 3 h after sporozoite inoculation at a time when sporozoites had entered hepatocytes, suggesting that it is recognizing and eliminating infected hepatocytes. These studies demonstrate that cytotoxic T lymphocytes against PySSP2 can protect against P. yoelii sporozoite challenge in the absence of other parasite-specific immune responses.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-1372647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-1409621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-1501644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-1517574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-1689762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-1704150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-1707538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-1716146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-1827210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-1903415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-1988490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-2094580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-2434426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-2447163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-2452443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-2456467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-2477703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-2524877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-2642947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-2963334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-2970507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-3085218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-3091507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-3119723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-3120015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-39127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-6991628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8005684-7679428
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2979-83
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8005684-Animals,
pubmed-meshheading:8005684-Antigens, CD8,
pubmed-meshheading:8005684-Clone Cells,
pubmed-meshheading:8005684-Female,
pubmed-meshheading:8005684-Immunotherapy, Adoptive,
pubmed-meshheading:8005684-Interferon-gamma,
pubmed-meshheading:8005684-Interleukins,
pubmed-meshheading:8005684-Malaria,
pubmed-meshheading:8005684-Mice,
pubmed-meshheading:8005684-Mice, Inbred BALB C,
pubmed-meshheading:8005684-Plasmodium yoelii,
pubmed-meshheading:8005684-Protozoan Proteins,
pubmed-meshheading:8005684-Recombinant Proteins,
pubmed-meshheading:8005684-T-Lymphocytes, Cytotoxic
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pubmed:year |
1994
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pubmed:articleTitle |
Complete protection against Plasmodium yoelii by adoptive transfer of a CD8+ cytotoxic T-cell clone recognizing sporozoite surface protein 2.
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pubmed:affiliation |
Malaria Program, Naval Medical Research Institute, Bethesda, Maryland 20889-5607.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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