| pubmed-article:7995938 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7995938 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:7995938 | lifeskim:mentions | umls-concept:C0085243 | lld:lifeskim |
| pubmed-article:7995938 | lifeskim:mentions | umls-concept:C1268930 | lld:lifeskim |
| pubmed-article:7995938 | lifeskim:mentions | umls-concept:C0751781 | lld:lifeskim |
| pubmed-article:7995938 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:7995938 | lifeskim:mentions | umls-concept:C0243067 | lld:lifeskim |
| pubmed-article:7995938 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7995938 | pubmed:dateCreated | 1995-1-19 | lld:pubmed |
| pubmed-article:7995938 | pubmed:abstractText | The scid mutation was backcrossed ten generations onto the NOD/Lt strain background, resulting in an immunodeficient stock (NOD/LtSz-scid/scid) with multiple defects in adaptive as well as nonadaptive immunologic function. NOD/LtSz-scid/scid mice lack functional lymphoid cells and show little or no serum Ig with age. Although NOD/(Lt-)+/+ mice develop T cell-mediated autoimmune, insulin-dependent diabetes mellitus, NOD/LtSz-scid/scid mice are both insulitis- and diabetes-free throughout life. However, because of a high incidence of thymic lymphomas, the mean lifespan of this congenic stock is only 8.5 mo under specific pathogen-free conditions. After i.v. injection of human CEM T-lymphoblastoid cells, splenic engraftment of these cells was fourfold greater in NOD/LtSz-scid/scid mice than in C.B17/Sz-scid/scid mice. Although C.B-17Sz-scid/scid mice exhibit robust NK cell activity, this activity is markedly reduced in both NOD/(Lt-)+/+ and NOD/LtSz-scid/scid mice. Presence of a functionally less mature macrophage population in NOD/LtSz-scid/scid vs C.B-17Sz-scid/scid mice is indicated by persistence in the former of the NOD/Lt strain-specific defect in LPS-stimulated IL-1 secretion by marrow-derived macrophages. Although C.B-17Sz-scid/scid and C57BL/6Sz-scid/scid mice have elevated serum hemolytic complement activity compared with their respective +/+ controls, both NOD/(LtSz-)+/+ and NOD/LtSz-scid/scid mice lack this activity. Age-dependent increases in serum Ig levels (> 1 micrograms/ml) were observed in only 2 of 30 NOD/LtSz-scid/scid mice vs 21 of 29 C.B-17/Sz-scid/scid animals. The multiple defects in innate and adaptive immunity unique to the NOD/LtSz-scid/scid mouse provide an excellent in vivo environment for reconstitution with human hematopoietic cells. | lld:pubmed |
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| pubmed-article:7995938 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7995938 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:7995938 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7995938 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7995938 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:7995938 | pubmed:author | pubmed-author:GotoII | lld:pubmed |
| pubmed-article:7995938 | pubmed:author | pubmed-author:GreinerD LDL | lld:pubmed |
| pubmed-article:7995938 | pubmed:author | pubmed-author:ShultzL DLD | lld:pubmed |
| pubmed-article:7995938 | pubmed:author | pubmed-author:McKennaSS | lld:pubmed |
| pubmed-article:7995938 | pubmed:author | pubmed-author:MobraatenLL | lld:pubmed |
| pubmed-article:7995938 | pubmed:author | pubmed-author:TennentBB | lld:pubmed |
| pubmed-article:7995938 | pubmed:author | pubmed-author:RajanT VTV | lld:pubmed |
| pubmed-article:7995938 | pubmed:author | pubmed-author:ChristiansonS... | lld:pubmed |
| pubmed-article:7995938 | pubmed:author | pubmed-author:SchweitzerP... | lld:pubmed |
| pubmed-article:7995938 | pubmed:author | pubmed-author:SchweitzerI... | lld:pubmed |
| pubmed-article:7995938 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7995938 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7995938 | pubmed:volume | 154 | lld:pubmed |
| pubmed-article:7995938 | pubmed:geneSymbol | Emv30 | lld:pubmed |
| pubmed-article:7995938 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7995938 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:7995938 | pubmed:pagination | 180-91 | lld:pubmed |
| pubmed-article:7995938 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:7995938 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7995938 | pubmed:articleTitle | Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. | lld:pubmed |
| pubmed-article:7995938 | pubmed:affiliation | Jackson Laboratory, Bar Harbor, ME 04609. | lld:pubmed |
| pubmed-article:7995938 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7995938 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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