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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1995-1-13
|
| pubmed:abstractText |
The ability of HrTNF-alpha, HrIL-1 beta, and HrIFN-gamma to modulate IL-6 production by cultured human salivary cell line (HSG) was examined. IL-6 activity was measured by the hybridoma growth factor biologic activity. HrTNF-alpha had a significant dose-dependent effect, whereas HrIL-1 beta and HrIFN-gamma had moderate and minor effects, respectively. Maximal effect (920 units) was noted when cytokines were applied in combination (1000 units HrIFN-gamma and 20 units HrTNF-alpha) and incubated with human salivary gland cells for 72 hr. The same combination of cytokines had also a marked inhibitory effect (70% of control) on human salivary gland cell growth. This is the first report of these concomitant phenomena in a human cell line originating from salivary tissue.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0008-8749
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
159
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
211-9
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:7994755-Cell Division,
pubmed-meshheading:7994755-Cell Line,
pubmed-meshheading:7994755-Cytokines,
pubmed-meshheading:7994755-Humans,
pubmed-meshheading:7994755-Interferon-gamma,
pubmed-meshheading:7994755-Interleukin-6,
pubmed-meshheading:7994755-Salivary Glands,
pubmed-meshheading:7994755-Tumor Necrosis Factor-alpha
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Cytokines modulate interleukin-6 production by human salivary gland cell line.
|
| pubmed:affiliation |
Heller Institute, Sheba Medical Center, Tel Aviv, Israel.
|
| pubmed:publicationType |
Journal Article
|