Linked Life Data

7987873

Source:http://linkedlifedata.com/resource/pubmed/id/7987873

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1995-1-10
pubmed:abstractText
To evaluate relaxation mechanics in the wall of the left ventricle needle mounted miniature pressure transducers were inserted at the subendocardial (ENDO) and subepicardial (EPI) level of the anterior wall of the left ventricle during acute open-chest experiments in 10 mongrel dogs. Pressures were recorded during control, volume load and after verapamil administration. The relaxation time constant (tau) was determined by fitting a monoexponential with offset to the isovolumic relaxation period of the ENDO, EPI and left ventricular pressure (LVP) tracings: p = p0e-t/tau + p1. Mean tau-values for LVP, ENDO and EPI during control were (mean +/- 1 SD, ms): 38 +/- 5, 60 +/- 12, 83 +/- 5; during volume overload: 55 +/- 10, 72 +/- 20, 85 +/- 31 and after verapamil administration: 58 +/- 13, 60 +/- 17 and 73 +/- 15, respectively. Relaxation time constants of ENDO and EPI were significantly longer than those of LVP during control and volume loading but not after verapamil when only EPI was significantly different from LVP. These results demonstrate that relaxation indices obtained from LVP may not always reflect intramyocardial mechanics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0008-6312
pubmed:author
pubmed:issnType
Print
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
175-83
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Relaxation within the left ventricular myocardial wall.
pubmed:affiliation
UZ Gasthuisberg, KU, Leuven, Belgium.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't