Linked Life Data

7958751

Source:http://linkedlifedata.com/resource/pubmed/id/7958751

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-12-28
pubmed:abstractText
Activin and inhibin, dimeric protein hormones originally isolated from mammalian gonads, are involved in the regulation of pituitary gonadotropin secretion. Using domain-specific antibodies against activin and inhibin alpha, beta A, and beta B subunits, the present study demonstrates that immunoreactive activin and inhibin subunits, especially beta A, exist in goldfish pituitary. Immunocytochemical staining with anti-gonadotropin-II and anti-growth hormone showed that the pituitary cells containing immunoreactive activin beta subunits are somatotrophs. This is different from the situation in mammals where it is the gonadotrophs that produce activin molecules within the pituitary. The staining with anti-beta B was overall weak compared to that with anti-beta A, but both appear to localize in the same cells. Strong immunostaining with the anti-inhibin alpha subunit was also observed in the goldfish pituitary; however, the immunoreactivity is dissociated from those of beta A and beta B, and mainly associated with nerve fibers in the neurointermediate lobe. Based on this evidence, it is suggested that the goldfish pituitary predominantly produced activin-like molecules. Both porcine activin and inhibin stimulate growth hormone release from perifused goldfish pituitary fragments. Taken together with our previous findings that porcine activin stimulates gonadotropin-II release in goldfish, and the fact that the somatotrophs and gonadotrophs are in close contact with each other in the goldfish pituitary, it is hypothesized that somatotroph-derived activin may exert paracrine actions on the adjacent gonadotrophs to stimulate gonadotropin release and autocrine actions on somatotrophs to stimulate growth hormone secretion. This also provides a mechanism for communication between these two pituitary cell types.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0016-6480
pubmed:author
pubmed:issnType
Print
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
213-21
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Activin-like peptides in somatotrophs and activin stimulation of growth hormone release in goldfish.
pubmed:affiliation
Department of Zoology, University of Alberta, Edmonton, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't