Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-11-16
pubmed:abstractText
We have studied the neurocognitive deficit in premutation and full mutation women as compared to control women and to explore the relationship between those deficits and the incidence of emotional problems. Four groups of women were examined: two fragile X (fra(X)) negative control groups, one of which grew up in fra(X) families and one not; and two DNA positive groups, one with a premutation (CGG repeats < 200) and one with an expanded mutation (CGG repeats > 200). All women were assessed using the MMPI-2, the SADS-L, and a battery of neuropsychological tests. Full mutation women had lower scores on composite measures of executive function and nonverbal function. There was no difference between the groups in terms of the lifetime incidence of depressive and anxiety disorders on the SADS-L. Full mutation women displayed Lie scales higher than the other groups on the MMPI-2. Neurocognitive measures were not related to SADS-L diagnoses but were related to the Lie scale on the MMPI-2. Finally, number of CGG repeats was related to the neuropsychological variables and the Lie scale.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0148-7299
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
51
pubmed:geneSymbol
FMR-1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
378-85
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:7943003-Adult, pubmed-meshheading:7943003-Analysis of Variance, pubmed-meshheading:7943003-Case-Control Studies, pubmed-meshheading:7943003-Chi-Square Distribution, pubmed-meshheading:7943003-Cognition Disorders, pubmed-meshheading:7943003-DNA Mutational Analysis, pubmed-meshheading:7943003-Female, pubmed-meshheading:7943003-Fragile X Syndrome, pubmed-meshheading:7943003-Heterozygote, pubmed-meshheading:7943003-Humans, pubmed-meshheading:7943003-Intelligence Tests, pubmed-meshheading:7943003-MMPI, pubmed-meshheading:7943003-Middle Aged, pubmed-meshheading:7943003-Mood Disorders, pubmed-meshheading:7943003-Mutation, pubmed-meshheading:7943003-Neuropsychological Tests, pubmed-meshheading:7943003-Regression Analysis, pubmed-meshheading:7943003-Repetitive Sequences, Nucleic Acid, pubmed-meshheading:7943003-Schizotypal Personality Disorder
pubmed:year
1994
pubmed:articleTitle
Emotional and neurocognitive deficits in fragile X.
pubmed:affiliation
Child Development Unit, Children's Hospital, Denver, Colorado 80218-1088.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't