Linked Life Data

7923920

Source:http://linkedlifedata.com/resource/pubmed/id/7923920

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-10-28
pubmed:abstractText
CD8+ T cell suppression of HIV replication in vitro was evaluated over 1-2 years in 12 HIV-infected individuals receiving daily dosages of Zidovudine (AZT) and in 9 untreated subjects. In the 12 AZT-treated patients, the level of CD8+ cell antiviral activity increased an average of 6.6-fold above pretreatment levels. These increases in antiviral activity observed were only transient in 6 of the subjects, returning to pretreatment levels, or lower, over the study period. In the other 4 subjects, the CD8+ cell antiviral response remained elevated at the end of the study period. The changes in CD8+ cell responses did not correlate with observed alterations in the absolute number or the percentage of CD4+ or CD8+ peripheral blood lymphocytes. Untreated HIV-infected subjects generally showed a gradual decrease in the CD8+ cell response over time to as much as 16-fold below baseline and in contrast to the treated group, these changes correlated with similar changes in CD4+ cell counts (P = 0.02). The average level of CD8+ cell antiviral activity observed over the entire study period was more than 2-fold above baseline in the 12 AZT-treated subjects, whereas it was more than 3-fold below baseline in the untreated subjects (P = 0.0001). Culturing CD8+ cells in the continued presence of AZT (1 microM) showed no effect on the ability of the cells to inhibit replication of an AZT-resistant HIV-1 strain. The results suggest that AZT therapy can have a beneficial effect, albeit often of limited duration, on CD8+ T cell function in HIV-infected individuals.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0090-1229
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
80-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Effect of zidovudine therapy on CD8+ T cell anti-HIV activity.
pubmed:affiliation
University of California, School of Medicine, San Francisco 94143-0128.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.