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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1977-1-25
|
| pubmed:abstractText |
Case records of 1,098 patients treated with amikacin at 79 research centers in 10 countries in a program of worldwide clinical trials were reviewed. Of the 697 patients eligible for use in evaluation of efficacy of the drug, 81% were cured, as evidenced by clinical remission and eradication of the infecting pathogen. The usual dosage was 7.5 mg/kg administered intramuscularly at 12-hr intervals. This dosage was modified in patients with renal impairment. Amikacin was effective in 90% of 322 patients with genitourinary infections, 85% of 97 patients with septicemia, 70% of 73 patients with infections of skin, soft tissue, or bone (excluding burns), and 69% of 68 patients with infections of the lower respiratory tract. Amikacin was effective in treatment of 88% of 85 infections due to gentamicin-resistant pathogens. The drug was generally well tolerated, and no side effects were reported in 80.6% of the 1,098 patients evaluated. Amikacin shares with other aminoglycosides the risk of ototoxicity and nephtotoxicity; previous exposure to gentamicin was a major factor in the development of such adverse effects. Other adverse reactions were relatively infrequent and in most cases were characterized as mild and transient.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
134 SUPPL
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
S441-5
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:792360-Adolescent,
pubmed-meshheading:792360-Adult,
pubmed-meshheading:792360-Aged,
pubmed-meshheading:792360-Amikacin,
pubmed-meshheading:792360-Bacterial Infections,
pubmed-meshheading:792360-Bone Diseases,
pubmed-meshheading:792360-Child,
pubmed-meshheading:792360-Child, Preschool,
pubmed-meshheading:792360-Clinical Trials as Topic,
pubmed-meshheading:792360-Drug Resistance, Microbial,
pubmed-meshheading:792360-Enterobacteriaceae Infections,
pubmed-meshheading:792360-Humans,
pubmed-meshheading:792360-Infant,
pubmed-meshheading:792360-Infant, Newborn,
pubmed-meshheading:792360-Kanamycin,
pubmed-meshheading:792360-Middle Aged,
pubmed-meshheading:792360-Pseudomonas Infections,
pubmed-meshheading:792360-Respiratory Tract Infections,
pubmed-meshheading:792360-Sepsis,
pubmed-meshheading:792360-Skin Diseases, Infectious,
pubmed-meshheading:792360-Urinary Tract Infections
|
| pubmed:year |
1976
|
| pubmed:articleTitle |
A review of results of clinical trials with amikacin.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial
|