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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-10-28
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pubmed:abstractText |
The p53 tumor suppressor gene is mutated in a large percentage of human malignancies, including tumors of the colon, breast, lung and brain. Individuals who inherit one mutant allele of p53 are susceptible to a wide range of tumor types. The gene encodes a transcriptional regulator that may function in the cellular response to DNA damage. The construction of mouse strains carrying germline mutations of p53 facilitates analysis of the function of p53 in normal cells and tumorigenesis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
4
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pubmed:geneSymbol |
p53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7922305-Alleles,
pubmed-meshheading:7922305-Animals,
pubmed-meshheading:7922305-Base Sequence,
pubmed-meshheading:7922305-Chimera,
pubmed-meshheading:7922305-Chromosome Deletion,
pubmed-meshheading:7922305-Crosses, Genetic,
pubmed-meshheading:7922305-DNA Damage,
pubmed-meshheading:7922305-DNA Primers,
pubmed-meshheading:7922305-Female,
pubmed-meshheading:7922305-Genes, p53,
pubmed-meshheading:7922305-Humans,
pubmed-meshheading:7922305-Li-Fraumeni Syndrome,
pubmed-meshheading:7922305-Male,
pubmed-meshheading:7922305-Mice,
pubmed-meshheading:7922305-Mice, Inbred C57BL,
pubmed-meshheading:7922305-Mice, Transgenic,
pubmed-meshheading:7922305-Molecular Sequence Data,
pubmed-meshheading:7922305-Neoplasms, Experimental,
pubmed-meshheading:7922305-Polymerase Chain Reaction,
pubmed-meshheading:7922305-Sequence Deletion,
pubmed-meshheading:7922305-Tumor Suppressor Protein p53
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pubmed:year |
1994
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pubmed:articleTitle |
Tumor spectrum analysis in p53-mutant mice.
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pubmed:affiliation |
Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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