Linked Life Data

7919190

Source:http://linkedlifedata.com/resource/pubmed/id/7919190

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1994-11-22
pubmed:abstractText
AMPA-preferring glutamate receptor genes gluR1-4 undergo alternative splicing into flip and flop mRNA isoforms. In the rodent hippocampus, gluR1 and gluR2 isoforms are differentially expressed. We have studied their distribution in human hippocampus. As in the rat, flop isoforms predominate over flip in dentate gyrus, whereas gluR1 flip is prominent only in CA3. In contrast to the rat, flop mRNAs are clearly present in CA3. At a cellular level, pyramidal neurones express moderate amounts of each isoform. In several hippocampal fields, scattered non-pyramidal cells--putatively interneurones and glia--show abundant expression. The findings are supported by immunocytochemical detection of gluR1 and gluR2/3. As the four encoded isoforms have distinct properties, their differential expression within the hippocampus, and between species, should be taken into account when considering the roles of AMPA receptors in normal and abnormal brain states.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
5
pubmed:geneSymbol
gluR1-4, gluRA-D
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1325-8
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
AMPA glutamate receptors and their flip and flop mRNAs in human hippocampus.
pubmed:affiliation
University Department of Psychiatry, Warneford Hospital, Oxford, UK.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't