Linked Life Data

7917158

Source:http://linkedlifedata.com/resource/pubmed/id/7917158

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1994-11-8
pubmed:abstractText
We compared the effects of angiotensin-converting enzyme inhibition with quinapril to those of selective beta-blockade with atenolol and calcium channel blockade with verapamil in 10 hypertensive subjects in a randomized double-blind placebo-controlled crossover study. All antihypertensive agents reduced baseline mean arterial pressure equally and did not modify forearm vascular resistance compared to placebo. In response to sustained handgrip exercise, both quinapril and verapamil, but not atenolol, attenuated the pressor response. However, verapamil was associated with an exaggerated increase in forearm vascular resistance during handgrip, whereas quinapril did not alter this response compared to placebo. It is concluded that quinapril and verapamil reduce the pressor response during isometric exercise by quantitatively different effects on the vasoconstrictor response in, as well as outside of, skeletal muscles.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0895-7061
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
566-70
pubmed:dateRevised
2009-2-24
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Comparative effects of quinapril, atenolol, and verapamil on blood pressure and forearm hemodynamics during handgrip exercise.
pubmed:affiliation
Hypertension Research Unit, CHUL Research Center, Université Laval, Québec, Canada.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't