| pubmed-article:7911434 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7911434 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7911434 | lifeskim:mentions | umls-concept:C0030498 | lld:lifeskim |
| pubmed-article:7911434 | lifeskim:mentions | umls-concept:C0039215 | lld:lifeskim |
| pubmed-article:7911434 | lifeskim:mentions | umls-concept:C0162615 | lld:lifeskim |
| pubmed-article:7911434 | lifeskim:mentions | umls-concept:C1621857 | lld:lifeskim |
| pubmed-article:7911434 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:7911434 | lifeskim:mentions | umls-concept:C1611645 | lld:lifeskim |
| pubmed-article:7911434 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:7911434 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7911434 | pubmed:dateCreated | 1994-7-12 | lld:pubmed |
| pubmed-article:7911434 | pubmed:abstractText | Immunocompetent mice are nonpermissive for the development and maturation of the human filarial parasite, Brugia malayi. We and others have shown that the absence of T-lymphocytes, alone or in combination with B-lymphocytes, renders mice permissive to infection. In a previous study, we showed that mice lacking CD8+ T-lymphocytes are also completely nonpermissive for B. malayi, indicating that CD8+ T-lymphocytes are not an obligate requirement for resistance. In the present study, we have examined the role of CD4+ T-lymphocytes in resistance to filarial infection using two experimental systems. In the first, we used an anti-CD4 monoclonal antibody to deplete CD4+ T-cells in vivo in immunocompetent BALB/c mice. In the second system, we used mutant mice in which the gene encoding the CD4 antigen had been disrupted by homologous recombination, resulting in a lack of CD4+ T-cells. Challenge of either the anti-CD4 antibody depleted BALB/c mice or CD4 knockout mice with B. malayi infective-stage larvae demonstrated that mice lacking CD4+ T-lymphocytes were resistant to infection. These data indicate that CD4+ T-cells are not an obligate requirement for murine resistance to B. malayi. | lld:pubmed |
| pubmed-article:7911434 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7911434 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7911434 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7911434 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7911434 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7911434 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7911434 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7911434 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7911434 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7911434 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7911434 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7911434 | pubmed:issn | 0014-4894 | lld:pubmed |
| pubmed-article:7911434 | pubmed:author | pubmed-author:GreinerD LDL | lld:pubmed |
| pubmed-article:7911434 | pubmed:author | pubmed-author:ShultzL DLD | lld:pubmed |
| pubmed-article:7911434 | pubmed:author | pubmed-author:LittmanD RDR | lld:pubmed |
| pubmed-article:7911434 | pubmed:author | pubmed-author:RajanT VTV | lld:pubmed |
| pubmed-article:7911434 | pubmed:author | pubmed-author:NelsonF KFK | lld:pubmed |
| pubmed-article:7911434 | pubmed:author | pubmed-author:KilleenNN | lld:pubmed |
| pubmed-article:7911434 | pubmed:author | pubmed-author:YatesJ AJA | lld:pubmed |
| pubmed-article:7911434 | pubmed:author | pubmed-author:BailitJ LJL | lld:pubmed |
| pubmed-article:7911434 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7911434 | pubmed:volume | 78 | lld:pubmed |
| pubmed-article:7911434 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7911434 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7911434 | pubmed:pagination | 352-60 | lld:pubmed |
| pubmed-article:7911434 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:7911434 | pubmed:meshHeading | pubmed-meshheading:7911434-... | lld:pubmed |
| pubmed-article:7911434 | pubmed:meshHeading | pubmed-meshheading:7911434-... | lld:pubmed |
| pubmed-article:7911434 | pubmed:meshHeading | pubmed-meshheading:7911434-... | lld:pubmed |
| pubmed-article:7911434 | pubmed:meshHeading | pubmed-meshheading:7911434-... | lld:pubmed |
| pubmed-article:7911434 | pubmed:meshHeading | pubmed-meshheading:7911434-... | lld:pubmed |
| pubmed-article:7911434 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7911434 | pubmed:articleTitle | CD4+ T-lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi. | lld:pubmed |
| pubmed-article:7911434 | pubmed:affiliation | Department of Pathology, University of Connecticut Health Center, Farmington 06030. | lld:pubmed |
| pubmed-article:7911434 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7911434 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7911434 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:12504 | entrezgene:pubmed | pubmed-article:7911434 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7911434 | lld:pubmed |
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