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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1994-7-12
|
| pubmed:abstractText |
Immunocompetent mice are nonpermissive for the development and maturation of the human filarial parasite, Brugia malayi. We and others have shown that the absence of T-lymphocytes, alone or in combination with B-lymphocytes, renders mice permissive to infection. In a previous study, we showed that mice lacking CD8+ T-lymphocytes are also completely nonpermissive for B. malayi, indicating that CD8+ T-lymphocytes are not an obligate requirement for resistance. In the present study, we have examined the role of CD4+ T-lymphocytes in resistance to filarial infection using two experimental systems. In the first, we used an anti-CD4 monoclonal antibody to deplete CD4+ T-cells in vivo in immunocompetent BALB/c mice. In the second system, we used mutant mice in which the gene encoding the CD4 antigen had been disrupted by homologous recombination, resulting in a lack of CD4+ T-cells. Challenge of either the anti-CD4 antibody depleted BALB/c mice or CD4 knockout mice with B. malayi infective-stage larvae demonstrated that mice lacking CD4+ T-lymphocytes were resistant to infection. These data indicate that CD4+ T-cells are not an obligate requirement for murine resistance to B. malayi.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0014-4894
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
78
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
352-60
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7911434-Animals,
pubmed-meshheading:7911434-Antibodies, Helminth,
pubmed-meshheading:7911434-Antibodies, Monoclonal,
pubmed-meshheading:7911434-Blotting, Western,
pubmed-meshheading:7911434-Brugia malayi,
pubmed-meshheading:7911434-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7911434-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:7911434-Female,
pubmed-meshheading:7911434-Filariasis,
pubmed-meshheading:7911434-Immunoglobulin Isotypes,
pubmed-meshheading:7911434-Leukocyte Count,
pubmed-meshheading:7911434-Lymphocyte Subsets,
pubmed-meshheading:7911434-Male,
pubmed-meshheading:7911434-Mice,
pubmed-meshheading:7911434-Mice, Inbred BALB C,
pubmed-meshheading:7911434-Mice, SCID,
pubmed-meshheading:7911434-Specific Pathogen-Free Organisms,
pubmed-meshheading:7911434-Spleen
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
CD4+ T-lymphocytes are not required for murine resistance to the human filarial parasite, Brugia malayi.
|
| pubmed:affiliation |
Department of Pathology, University of Connecticut Health Center, Farmington 06030.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|