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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1995-3-14
|
| pubmed:abstractText |
The gamma-aminobutyric acid receptor (GABAAR) is a multisubunit Cl- channel that mediates most fast inhibitory synaptic transmission in the central nervous system. Molecular evolution has given rise to many genetic variants of GABAAR subunits, including alpha 1-6, beta 1-4, gamma 1-4, delta, and rho 1-2, suggesting that an enormous number of combinations of subunits are possible. Here we report that the beta 2 gene is located on chromosome 5q34-q35, defining a cluster comprising alpha 1, beta 2, and gamma 2 genes that together code for the most abundant GABAAR isoform. The fact that intron position is conserved in the beta 1-3 genes, taken together with the observation that chromosomes 4 and 15 also contain distinct alpha-beta-gamma gene clusters, strongly suggests that an ancestral alpha-beta-gamma cluster was duplicated and translocated to at least two different chromosomes. This organization of GABAAR gene clusters may have been preserved as linkage provides a mechanism for facilitating coordinate gene expression.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0888-7543
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
23
|
| pubmed:geneSymbol |
GABRB2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
528-33
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:7851879-Amino Acid Sequence,
pubmed-meshheading:7851879-Animals,
pubmed-meshheading:7851879-Base Sequence,
pubmed-meshheading:7851879-Biological Evolution,
pubmed-meshheading:7851879-Chickens,
pubmed-meshheading:7851879-Chromosome Mapping,
pubmed-meshheading:7851879-Chromosomes, Human, Pair 5,
pubmed-meshheading:7851879-Conserved Sequence,
pubmed-meshheading:7851879-DNA Primers,
pubmed-meshheading:7851879-Exons,
pubmed-meshheading:7851879-Hominidae,
pubmed-meshheading:7851879-Humans,
pubmed-meshheading:7851879-Hybrid Cells,
pubmed-meshheading:7851879-Introns,
pubmed-meshheading:7851879-Macromolecular Substances,
pubmed-meshheading:7851879-Mice,
pubmed-meshheading:7851879-Molecular Sequence Data,
pubmed-meshheading:7851879-Multigene Family,
pubmed-meshheading:7851879-Polymerase Chain Reaction,
pubmed-meshheading:7851879-Rats,
pubmed-meshheading:7851879-Receptors, GABA-A,
pubmed-meshheading:7851879-Sequence Homology, Amino Acid
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Mapping of the beta 2 subunit gene (GABRB2) to microdissected human chromosome 5q34-q35 defines a gene cluster for the most abundant GABAA receptor isoform.
|
| pubmed:affiliation |
Department of Pharmacology, Boston University School of Medicine, Massachusetts 02118.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|