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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1995-3-6
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pubmed:abstractText |
In this paper the identity of the salivary protein EP-GP (extra-parotid glycoprotein) is reported, also apparent in other human secretions. Immunochemical and biochemical analysis demonstrated that EP-GP is similar to the secretory actin-binding protein (SABP), also known as gross cystic disease fluid protein-15 (GCDFP-15) and prolactin-inducible protein (PIP). The molecular mass and charge microheterogeneity of EP-GP, also observed for SABP, was shown to be predominantly caused by the carbohydrate moiety. In addition, evidence was given that EP-GP is not related to the lipocalin Von Ebner's gland protein (human; VEGh). The biological significance of EP-GP and its homologues is not clear. EP-GP bound to actin and fibrinogen as described for SABP and GCDFP-15. However, the affinity for these proteins does not appear to have any direct physiological role in the mucosal secretions. On the other hand, EP-GP binds to several bacteria. By electron microscopy the ultrastructural localization is demonstrated of EP-GP to the cell wall of both Streptococcus salivarius HB and its cell appendage-lacking mutant Streptococcus salivarius HB-C12. Concerning this finding we hypothesize on the possible functional aspects of this enigmatic protein EP-GP.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/APOD protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins D,
http://linkedlifedata.com/resource/pubmed/chemical/Carbohydrates,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Microfilament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PIP protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Salivary Proteins and Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/extra parotid glycoprotein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0177-3593
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
375
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
609-15
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7840903-Amino Acid Sequence,
pubmed-meshheading:7840903-Apolipoproteins,
pubmed-meshheading:7840903-Apolipoproteins D,
pubmed-meshheading:7840903-Carbohydrates,
pubmed-meshheading:7840903-Carrier Proteins,
pubmed-meshheading:7840903-Cell Wall,
pubmed-meshheading:7840903-Glycoproteins,
pubmed-meshheading:7840903-Humans,
pubmed-meshheading:7840903-Immunoblotting,
pubmed-meshheading:7840903-Kinetics,
pubmed-meshheading:7840903-Male,
pubmed-meshheading:7840903-Membrane Transport Proteins,
pubmed-meshheading:7840903-Microfilament Proteins,
pubmed-meshheading:7840903-Microscopy, Electron,
pubmed-meshheading:7840903-Molecular Sequence Data,
pubmed-meshheading:7840903-Molecular Weight,
pubmed-meshheading:7840903-Organ Specificity,
pubmed-meshheading:7840903-Salivary Proteins and Peptides,
pubmed-meshheading:7840903-Semen,
pubmed-meshheading:7840903-Seminal Vesicles,
pubmed-meshheading:7840903-Sequence Homology, Amino Acid,
pubmed-meshheading:7840903-Streptococcus,
pubmed-meshheading:7840903-Submandibular Gland
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pubmed:year |
1994
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pubmed:articleTitle |
Identity of human extra parotid glycoprotein (EP-GP) with secretory actin binding protein (SABP) and its biological properties.
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pubmed:affiliation |
Department of Oral Biochemistry, Vrije Universiteit, Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Comparative Study
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