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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1995-2-3
|
| pubmed:databankReference | |
| pubmed:abstractText |
In small mammals, the cardiac alpha-myosin heavy chain (MyHC) gene is predominantly expressed in the adult ventricle, while the beta-MyHC gene is predominantly expressed in the fetal ventricle. In order to perform comparative studies of these genes, we sequenced the Syrian hamster alpha-MyHC gene by determining a continuous 32,415 base pair (bp) sequence. It contained 39 exons encoding a predicted polypeptide of 1939 amino acid residues (aa) with a molecular weight of 223,644 Da. Sequence comparison revealed that the coding sequence is highly identical to that of the human alpha-MyHC gene. A marked feature of the Syrian hamster alpha-MyHC gene was the abundance of reiterated sequences within introns. Eleven B1 and four B2 retroposons were identified, a variety of di-, tri-, and tetra-nucleotide repeats were present, and three longer direct repeats were found. Some of them appear to be associated with genetic recombination events.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0022-2828
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
26
|
| pubmed:geneSymbol |
alpha-MyHC
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1155-65
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:7815459-Amino Acid Sequence,
pubmed-meshheading:7815459-Animals,
pubmed-meshheading:7815459-Base Sequence,
pubmed-meshheading:7815459-Cloning, Molecular,
pubmed-meshheading:7815459-Cricetinae,
pubmed-meshheading:7815459-Cricetulus,
pubmed-meshheading:7815459-DNA,
pubmed-meshheading:7815459-DNA Primers,
pubmed-meshheading:7815459-Gene Expression,
pubmed-meshheading:7815459-Humans,
pubmed-meshheading:7815459-Mesocricetus,
pubmed-meshheading:7815459-Mice,
pubmed-meshheading:7815459-Molecular Sequence Data,
pubmed-meshheading:7815459-Myosins,
pubmed-meshheading:7815459-Rats,
pubmed-meshheading:7815459-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:7815459-Restriction Mapping,
pubmed-meshheading:7815459-Sequence Homology, Amino Acid
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Characterization and nucleotide sequence of the cardiac alpha-myosin heavy chain gene from Syrian hamster.
|
| pubmed:affiliation |
Laboratory for Molecular Cardiology, Toronto Hospital, Canada.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|