Linked Life Data

7801431

Source:http://linkedlifedata.com/resource/pubmed/id/7801431

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1995-1-24
pubmed:abstractText
Testicular maturation was assessed in age-matched, sexually immature (13-17-week-old) New Zealand white rabbits using end points frequently evaluated in toxicity studies: testicular weight and testicular histology. Testicular weights and testicular maturity as assessed histologically were markedly variable in sexually immature rabbits, especially at > or = 14 weeks of age. The large variation in testicular weights in immature rabbits requires that large changes in a treatment group relative to controls be present for statistical detection of testicular weight effects at commonly used significance levels. Testicular weights and testicular maturity were strongly correlated to one another, but neither weight nor maturity was strongly correlated to body weight. Thus, stratification and randomization of immature rabbits to study groups based upon body weight will not assure an absence of group differences with respect to testicular maturity. The large variation in testicular weights and maturity in 13-17-week-old rabbits warrants caution in the evaluation of testicular changes when rabbits of this age range are used in toxicity studies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0300-9858
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
541-5
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Testicular maturation in prepubertal New Zealand white rabbits.
pubmed:affiliation
Haskell Laboratory for Toxicology and Industrial Medicine, E. I. du Pont de Nemours and Co., Newark, DE.
pubmed:publicationType
Journal Article