Linked Life Data

7778261

Source:http://linkedlifedata.com/resource/pubmed/id/7778261

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-7-11
pubmed:abstractText
This study provides baseline information on the potential use of propofol as a general anesthetic for horses. Using a Latin square design, propofol (2, 4, and 8 mg/kg) was administered intravenously on three separate occasions to six mature horses. Information about anesthetic induction, duration, and recovery was recorded along with results of rectal temperature, heart rate, respiratory rate, pHa, PaCO2 and PaO2. Statistical analysis included a mixed model analysis of variance, a general linear model analysis and least square means test for post hoc comparisons. A P < .05 was considered significant. The quality of induction of anesthesia varied from poor to good. Two horses were not recumbent following the lowest dose of propofol. Brief paddling limb movements occurred occasionally and unpredictably after recumbency induced by all three doses. During recovery, horses were uniformly calm and coordinated in their moves to stand. Duration of recumbency (minutes) was dose related; 15.05 +/- 1.58 (mean +/- SD) following 2 mg/kg, 31.06 +/- 5.56 following 4 mg/kg, and 47.85 +/- 13.63 following 8 mg/kg. During recumbency at all doses, heart rate significantly increased from a predrug value of 40 +/- 6 beats per minute. Substantial respiratory depression, characterized by a significant decrease in respiratory rate (from 11.7 +/- 2.9 to 3.7 +/- 1.6 breaths per minute) and increased PaCO2 (from 44.5 +/- 2.5 to 52.7 +/- 8.0 mm Hg) was seen only after 8 mg/kg. A significant decrease in PaO2 was observed throughout the recumbency induced by 8 mg/kg, and also at 3 and 5 minutes following induction of anesthesia with 4 mg/kg propofol.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0161-3499
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
188-94
pubmed:dateRevised
2011-4-25
pubmed:meshHeading
pubmed:articleTitle
Evaluation of propofol as a general anesthetic for horses.
pubmed:affiliation
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616-8745, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't