| pubmed-article:7755940 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7755940 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:7755940 | lifeskim:mentions | umls-concept:C0014792 | lld:lifeskim |
| pubmed-article:7755940 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:7755940 | lifeskim:mentions | umls-concept:C0333117 | lld:lifeskim |
| pubmed-article:7755940 | lifeskim:mentions | umls-concept:C0085580 | lld:lifeskim |
| pubmed-article:7755940 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:7755940 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:7755940 | lifeskim:mentions | umls-concept:C1621574 | lld:lifeskim |
| pubmed-article:7755940 | lifeskim:mentions | umls-concept:C0597484 | lld:lifeskim |
| pubmed-article:7755940 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7755940 | pubmed:dateCreated | 1995-6-29 | lld:pubmed |
| pubmed-article:7755940 | pubmed:abstractText | The goal of this study was to investigate the activity of the Na+/H+ exchanger in erythrocytes of patients with essential hypertension and its relation with urinary Na+ excretion. The study was performed in cells from 27 untreated hypertensive patients and 30 normotensive controls with similar age and sex distribution. All subjects were studied after 4 days on a controlled Na+ diet (145 mmol/day). The activity of the Na+/H+ exchanger was determined by acidifying cell pH and measuring the initial rate of the net Na(+)-dependent H+ efflux. The activity of the Na+/H+ exchanger was higher in hypertensive patients than in controls (301 +/- 45 v 162 +/- 23 mmol/L cells/h, mean +/- SEM; P < .01). With the upper limit of the normotensive population as a cut-off point (385 mmol/L cells/h), a subgroup of 12 hypertensive patients had an abnormally high activity of Na+/H+ exchanger. Compared with controls and with patients with normal exchanger activity, patients with increased exchanger activity were characterized by lower net (P < .01) and fractional (P < .05) Na+ excretion. The accumulative Na+ balance was higher (P < .01) in hypertensive patients with increased activity of the exchanger (39.90 +/- 3.47 mmol) than in the remaining hypertensive patients (0.59 +/- 6.96 mmol) or in the normotensive population (-5.71 +/- 6.12 mmol). After analyzing the relationship of renin activity with Na+ excretion it was observed that renin activity was inappropriately low in 9 (75%) patients with increased exchanger, in 6 (40%) patients with normal exchanger, and in 6 (20%) normotensives, these differences being significant (P<.01). | lld:pubmed |
| pubmed-article:7755940 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7755940 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7755940 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7755940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7755940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7755940 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7755940 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:7755940 | pubmed:issn | 0895-7061 | lld:pubmed |
| pubmed-article:7755940 | pubmed:author | pubmed-author:AlonsoAA | lld:pubmed |
| pubmed-article:7755940 | pubmed:author | pubmed-author:LópezRR | lld:pubmed |
| pubmed-article:7755940 | pubmed:author | pubmed-author:DíezJJ | lld:pubmed |
| pubmed-article:7755940 | pubmed:author | pubmed-author:ArrázolaAA | lld:pubmed |
| pubmed-article:7755940 | pubmed:author | pubmed-author:GarciandíaAA | lld:pubmed |
| pubmed-article:7755940 | pubmed:author | pubmed-author:Gómez-Alamill... | lld:pubmed |
| pubmed-article:7755940 | pubmed:author | pubmed-author:FortuñoAA | lld:pubmed |
| pubmed-article:7755940 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7755940 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:7755940 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7755940 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7755940 | pubmed:pagination | 124-32 | lld:pubmed |
| pubmed-article:7755940 | pubmed:dateRevised | 2009-2-24 | lld:pubmed |
| pubmed-article:7755940 | pubmed:meshHeading | pubmed-meshheading:7755940-... | lld:pubmed |
| pubmed-article:7755940 | pubmed:meshHeading | pubmed-meshheading:7755940-... | lld:pubmed |
| pubmed-article:7755940 | pubmed:meshHeading | pubmed-meshheading:7755940-... | lld:pubmed |
| pubmed-article:7755940 | pubmed:meshHeading | pubmed-meshheading:7755940-... | lld:pubmed |
| pubmed-article:7755940 | pubmed:meshHeading | pubmed-meshheading:7755940-... | lld:pubmed |
| pubmed-article:7755940 | pubmed:meshHeading | pubmed-meshheading:7755940-... | lld:pubmed |
| pubmed-article:7755940 | pubmed:meshHeading | pubmed-meshheading:7755940-... | lld:pubmed |
| pubmed-article:7755940 | pubmed:meshHeading | pubmed-meshheading:7755940-... | lld:pubmed |
| pubmed-article:7755940 | pubmed:meshHeading | pubmed-meshheading:7755940-... | lld:pubmed |
| pubmed-article:7755940 | pubmed:meshHeading | pubmed-meshheading:7755940-... | lld:pubmed |
| pubmed-article:7755940 | pubmed:meshHeading | pubmed-meshheading:7755940-... | lld:pubmed |
| pubmed-article:7755940 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7755940 | pubmed:articleTitle | Association of increased erythrocyte Na+/H+ exchanger with renal Na+ retention in patients with essential hypertension. | lld:pubmed |
| pubmed-article:7755940 | pubmed:affiliation | Department of Internal Medicine, School of Medicine, University of Navarra, Pamplona, Spain. | lld:pubmed |
| pubmed-article:7755940 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7755940 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7755940 | lld:pubmed |
