| pubmed-article:7749724 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7749724 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:7749724 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7749724 | lifeskim:mentions | umls-concept:C0014442 | lld:lifeskim |
| pubmed-article:7749724 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:7749724 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:7749724 | lifeskim:mentions | umls-concept:C0045438 | lld:lifeskim |
| pubmed-article:7749724 | lifeskim:mentions | umls-concept:C0286932 | lld:lifeskim |
| pubmed-article:7749724 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:7749724 | pubmed:dateCreated | 1995-6-21 | lld:pubmed |
| pubmed-article:7749724 | pubmed:abstractText | The induction of hepatic drug-metabolizing enzymes by chlornitrofen (CNP) and CNP-amino was studied in the liver of male rats and mice. CNP-amino increased the activities of 7-pentoxyresorufin O-depentylase (PROD) and 7-benzyloxyresorufin O-debenzylase (BROD) as CYP2B1-dependent monooxygenase 3.6- and 4.1-fold in rats. On the contrary, these enzyme activities in mice were induced by CNP rather than by CNP-amino. Furthermore, immunoblotting showed that the protein levels of CYP2B subfamily cytochrome P450 (P450) in liver microsomes of rats and mice were increased by CNP or CNP-amino. Phase II drug-metabolizing enzymes, UDP-glucuronyltransferase (UGT) and glutathione S-transferase (GST) levels in mice were also significantly increased from 1.4 to 2.5-fold by CNP or CNP-amino. However, neither CNP nor CNP-amino affected UGT and GST in rats. These results suggest that CNP and or CNP-amino induce the P450 isoforms of CYP2B subfamily in the rat and mouse liver, and that the inducibility of drug-metabolizing enzyme by the compounds is different between rats and mice. | lld:pubmed |
| pubmed-article:7749724 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7749724 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7749724 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7749724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7749724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7749724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7749724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7749724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7749724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7749724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7749724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7749724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7749724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7749724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7749724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7749724 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7749724 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7749724 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7749724 | pubmed:issn | 0045-6535 | lld:pubmed |
| pubmed-article:7749724 | pubmed:author | pubmed-author:AndoMM | lld:pubmed |
| pubmed-article:7749724 | pubmed:author | pubmed-author:NishimuraTT | lld:pubmed |
| pubmed-article:7749724 | pubmed:author | pubmed-author:TakahashiAA | lld:pubmed |
| pubmed-article:7749724 | pubmed:author | pubmed-author:NakanoKK | lld:pubmed |
| pubmed-article:7749724 | pubmed:author | pubmed-author:HaniokaNN | lld:pubmed |
| pubmed-article:7749724 | pubmed:author | pubmed-author:YodaRR | lld:pubmed |
| pubmed-article:7749724 | pubmed:author | pubmed-author:HamamuraMM | lld:pubmed |
| pubmed-article:7749724 | pubmed:author | pubmed-author:JinnoHH | lld:pubmed |
| pubmed-article:7749724 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7749724 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:7749724 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7749724 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7749724 | pubmed:pagination | 1297-309 | lld:pubmed |
| pubmed-article:7749724 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7749724 | pubmed:meshHeading | pubmed-meshheading:7749724-... | lld:pubmed |
| pubmed-article:7749724 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7749724 | pubmed:articleTitle | Induction of hepatic drug-metabolizing enzymes by chlornitrofen (CNP) and CNP-amino in rats and mice. | lld:pubmed |
| pubmed-article:7749724 | pubmed:affiliation | Division of Environmental Chemistry, National Institute of Health Sciences, Tokyo, Japan. | lld:pubmed |
| pubmed-article:7749724 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7749724 | lld:pubmed |
