Linked Life Data

7733912

Source:http://linkedlifedata.com/resource/pubmed/id/7733912

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-5-30
pubmed:abstractText
Since the role of intrinsic inactivation of the receptor for inositol 1,4,5-trisphosphate (InsP3) in the phenomenon of quantal release of Ca2+ is still a point of debate, we investigated whether inactivation of the InsP3 receptor can be responsible for quantal release in permeabilized A7r5 cells. A crucial experiment was that a second challenge of the cells with a low dose of InsP3, after washing out the first challenge, was unable to produce a renewed phasic response under conditions where the Ca2+ pumps were blocked. A new phasic response was however obtained with either addition of a higher dose of InsP3 or after allowing the refilling of the Ca2+ stores. We conclude therefore that quantal Ca2+ release in A7r5 cells is not due to InsP3 receptor inactivation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
209
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
451-6
pubmed:dateRevised
2007-7-18
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Quantal release of calcium in permeabilized A7r5 cells is not caused by intrinsic inactivation of the inositol trisphosphate receptor.
pubmed:affiliation
Laboratorium voor Fysiologie, K.U.Leuven Campus Gasthuisberg O/N, Belgium.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't