| pubmed-article:7718896 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7718896 | lifeskim:mentions | umls-concept:C0019034 | lld:lifeskim |
| pubmed-article:7718896 | lifeskim:mentions | umls-concept:C0600031 | lld:lifeskim |
| pubmed-article:7718896 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:7718896 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:7718896 | pubmed:dateCreated | 1995-5-25 | lld:pubmed |
| pubmed-article:7718896 | pubmed:abstractText | The incidence of functional asplenia in sickle-hemoglobin C (SC) disease has not been defined, and the use of prophylactic penicillin to prevent life-threatening septicemia in this disorder is controversial. The percentage of red blood cells with pits (pit count) is a reliable assay of splenic function in other disorders but has not been validated in hemoglobin SC disease. To address these issues, we conducted a prospective, multicenter study of splenic function in persons with hemoglobin SC disease. Baseline clinical data were recorded, and red blood cell pit counts were performed on 201 subjects, aged 6 months to 90 years, with hemoglobin SC; 43 subjects underwent radionuclide liver-spleen scanning. Pit counts greater than 20% were associated with functional asplenia as assessed by liver-spleen scan, whereas pit counts less than 20% were found in subjects with preserved splenic function. Pit counts greater than 20% were present in 0 of 59 subjects (0%) less than 4 years of age, in 19 of 86 subjects (22%) 4 to 12 years of age, and in 25 of 56 subjects (45%) greater than 12 years of age. Other subjects with hemoglobin SC, who had previously undergone surgical splenectomy, had higher pit counts (59.7% +/- 9.5%) than splenectomized subjects without hemoglobinopathy (38.5% +/- 8.8%) or with sickle cell anemia (20.5% +/- 1.9%; P < .001). Two subjects with hemoglobin SC disease (not splenectomized), ages 14 and 15 years, with pit counts of 40.3% and 41.7% died from pneumococcal septicemia. These data indicate that functional asplenia occurs in many patients with hemoglobin SC disease, but its development is usually delayed until after 4 years of age. The pit count is a reliable measure of splenic function in hemoglobin SC disease, but values indicative of functional asplenia (> 20% in our laboratory) are higher than in other disorders. The routine administration of prophylactic penicillin to infants and young children with hemoglobin SC disease may not be necessary. | lld:pubmed |
| pubmed-article:7718896 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7718896 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7718896 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7718896 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7718896 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7718896 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7718896 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7718896 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:7718896 | pubmed:author | pubmed-author:WethersD LDL | lld:pubmed |
| pubmed-article:7718896 | pubmed:author | pubmed-author:LuckeyD WDW | lld:pubmed |
| pubmed-article:7718896 | pubmed:author | pubmed-author:WoodsG MGM | lld:pubmed |
| pubmed-article:7718896 | pubmed:author | pubmed-author:BuchananG RGR | lld:pubmed |
| pubmed-article:7718896 | pubmed:author | pubmed-author:RogersZ RZR | lld:pubmed |
| pubmed-article:7718896 | pubmed:author | pubmed-author:LaneP APA | lld:pubmed |
| pubmed-article:7718896 | pubmed:author | pubmed-author:LearJ LJL | lld:pubmed |
| pubmed-article:7718896 | pubmed:author | pubmed-author:O'ConnellJ... | lld:pubmed |
| pubmed-article:7718896 | pubmed:author | pubmed-author:HassellK LKL | lld:pubmed |
| pubmed-article:7718896 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7718896 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:7718896 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:7718896 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7718896 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7718896 | pubmed:pagination | 2238-44 | lld:pubmed |
| pubmed-article:7718896 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:meshHeading | pubmed-meshheading:7718896-... | lld:pubmed |
| pubmed-article:7718896 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7718896 | pubmed:articleTitle | Functional asplenia in hemoglobin SC disease. | lld:pubmed |
| pubmed-article:7718896 | pubmed:affiliation | Colorado Sickle Cell Treatment and Research Center, University of Colorado School of Medicine, Denver, USA. | lld:pubmed |
| pubmed-article:7718896 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7718896 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7718896 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:7718896 | pubmed:publicationType | Multicenter Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7718896 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7718896 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7718896 | lld:pubmed |
