| pubmed-article:7706306 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7706306 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:7706306 | lifeskim:mentions | umls-concept:C0016006 | lld:lifeskim |
| pubmed-article:7706306 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:7706306 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:7706306 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:7706306 | lifeskim:mentions | umls-concept:C2753498 | lld:lifeskim |
| pubmed-article:7706306 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:7706306 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:7706306 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:7706306 | pubmed:dateCreated | 1995-5-10 | lld:pubmed |
| pubmed-article:7706306 | pubmed:abstractText | The three fibrinogen genes belong to the class II hepatic acute phase proteins that are regulated in part by members of the interleukin-6 (IL-6) family of cytokines and glucocorticoids. The common DNA sequence that characterizes this group of proteins is a hexanucleotide CTGGGA residing in the promoter regions of these genes. Investigations of IL-6 control of the A alpha fibrinogen gene by electrophoretic mobility shift assays using a 30-base pair DNA probe containing the CTGGGA element revealed that a novel protein is associated with this site during non-IL-6-stimulated conditions. Sensitive time-course studies of IL-6 stimulation using primary hepatocyte cultures, high resolution polyacrylamide gel electrophoresis, and site-directed mutagenesis show that upon IL-6 stimulation of hepatocytes, this DNA binding protein transiently leaves the CTGGGA site and binds 12 base pairs down-stream but then begins to re-associate with the original DNA site at 1 h and is completed by 2 h. A recently characterized and cloned IL-6-activated transcription factor, Stat-3, which has been reported to bind a CT-GGGAA site in the alpha-2 macroglobulin gene, another member of the class II acute phase proteins, does not bind to the CTGGGA sequence in the A alpha fibrinogen gene. These findings reveal the presence of a previously undefined IL-6-regulated event, which involves a new DNA binding protein and demonstrates for the first time additional details of the kinetics of IL-6 control of fibrinogen gene expression. | lld:pubmed |
| pubmed-article:7706306 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7706306 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7706306 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7706306 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7706306 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7706306 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:7706306 | pubmed:author | pubmed-author:LimRR | lld:pubmed |
| pubmed-article:7706306 | pubmed:author | pubmed-author:FullerG MGM | lld:pubmed |
| pubmed-article:7706306 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7706306 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:7706306 | pubmed:volume | 270 | lld:pubmed |
| pubmed-article:7706306 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7706306 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7706306 | pubmed:pagination | 7580-6 | lld:pubmed |
| pubmed-article:7706306 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:7706306 | pubmed:meshHeading | pubmed-meshheading:7706306-... | lld:pubmed |
| pubmed-article:7706306 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7706306 | pubmed:articleTitle | Detection of a novel transcription factor for the A alpha fibrinogen gene in response to interleukin-6. | lld:pubmed |
| pubmed-article:7706306 | pubmed:affiliation | Department of Cell Biology, University of Alabama at Birmingham 35294-0005, USA. | lld:pubmed |
| pubmed-article:7706306 | pubmed:publicationType | Journal Article | lld:pubmed |
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