Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-5-3
pubmed:databankReference
pubmed:abstractText
Most Ewing's sarcomas or related primitive neuroectodermal tumors have the (11;22)(q24;q12) or less frequently the (21;22)(q22;q12) translocation. These rearrangements fuse the EWS gene on chromosome 22q12 to either the FLI1 or ERG genes, both members of the ETS family of transcription factors. Simple variant chromosomal translocations have been occasionally described in these tumors. We have identified a third Ewing's sarcoma translocation, the t(7;22)(p22;q12), that fuses EWS to the human homologue of the murine ETS gene ER81. This gene, designated ETV1 (for ETS Translocation Variant), is located on chromosome band 7p22. Identical EWS nucleotide sequences found in the majority of EWS-FLI1 and EWS-ERG chimeric transcripts are fused to a portion of ETV1 encoding an ETS domain with sequence specific DNA-binding activity. These findings confirm that the fusion of EWS to different ETS family members can result in a similar tumor phenotype.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0950-9232
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
10
pubmed:geneSymbol
ETV1, EWS
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1229-34
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:7700648-Adult, pubmed-meshheading:7700648-Amino Acid Sequence, pubmed-meshheading:7700648-Animals, pubmed-meshheading:7700648-Base Sequence, pubmed-meshheading:7700648-Child, Preschool, pubmed-meshheading:7700648-Chromosomes, Human, Pair 22, pubmed-meshheading:7700648-Chromosomes, Human, Pair 7, pubmed-meshheading:7700648-Cloning, Molecular, pubmed-meshheading:7700648-DNA, Complementary, pubmed-meshheading:7700648-DNA-Binding Proteins, pubmed-meshheading:7700648-Female, pubmed-meshheading:7700648-Fetus, pubmed-meshheading:7700648-Heterogeneous-Nuclear Ribonucleoproteins, pubmed-meshheading:7700648-Humans, pubmed-meshheading:7700648-Mice, pubmed-meshheading:7700648-Molecular Sequence Data, pubmed-meshheading:7700648-Nuclear Proteins, pubmed-meshheading:7700648-RNA, Messenger, pubmed-meshheading:7700648-RNA-Binding Protein EWS, pubmed-meshheading:7700648-RNA-Binding Proteins, pubmed-meshheading:7700648-Recombinant Fusion Proteins, pubmed-meshheading:7700648-Ribonucleoproteins, pubmed-meshheading:7700648-Sarcoma, Ewing, pubmed-meshheading:7700648-Sequence Homology, Amino Acid, pubmed-meshheading:7700648-Transcription Factors, pubmed-meshheading:7700648-Translocation, Genetic
pubmed:year
1995
pubmed:articleTitle
A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1.
pubmed:affiliation
Department of Experimental Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't