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pubmed-article:7695900pubmed:abstractTextThe targeting of sensory afferent neurons in the leech CNS occurs in two discrete steps that are mediated via different carbohydrate recognitions, as shown by molecular perturbations of cultured embryos. A constitutive carbohydrate marker that is generic to all of these neurons mediates their initial defasciculation and arborization across the entire target region via mannose-specific recognition. Subsequently, two subsets of these same neurons can be differentiated by their expression of other markers that are located on hybrid or complex type carbohydrate chains. These developmentally regulated carbohydrate markers then mediate the target assembly of their respective neuronal subsets into discrete subregions. Thus, by performing opposing functions in a temporal sequence, constitutive and developmentally regulated carbohydrate markers collaborate in the targeting of neuronal subsets in the CNS.lld:pubmed
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pubmed-article:7695900pubmed:articleTitleTargeting of neuronal subsets mediated by their sequentially expressed carbohydrate markers.lld:pubmed
pubmed-article:7695900pubmed:affiliationDepartment of Physiology Michigan State University East Lansing 48824.lld:pubmed
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