Linked Life Data

7695900

Source:http://linkedlifedata.com/resource/pubmed/id/7695900

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-5-1
pubmed:abstractText
The targeting of sensory afferent neurons in the leech CNS occurs in two discrete steps that are mediated via different carbohydrate recognitions, as shown by molecular perturbations of cultured embryos. A constitutive carbohydrate marker that is generic to all of these neurons mediates their initial defasciculation and arborization across the entire target region via mannose-specific recognition. Subsequently, two subsets of these same neurons can be differentiated by their expression of other markers that are located on hybrid or complex type carbohydrate chains. These developmentally regulated carbohydrate markers then mediate the target assembly of their respective neuronal subsets into discrete subregions. Thus, by performing opposing functions in a temporal sequence, constitutive and developmentally regulated carbohydrate markers collaborate in the targeting of neuronal subsets in the CNS.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0896-6273
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
537-47
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Targeting of neuronal subsets mediated by their sequentially expressed carbohydrate markers.
pubmed:affiliation
Department of Physiology Michigan State University East Lansing 48824.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.