| pubmed-article:7692269 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7692269 | lifeskim:mentions | umls-concept:C0374711 | lld:lifeskim |
| pubmed-article:7692269 | lifeskim:mentions | umls-concept:C0043240 | lld:lifeskim |
| pubmed-article:7692269 | lifeskim:mentions | umls-concept:C0242606 | lld:lifeskim |
| pubmed-article:7692269 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:7692269 | lifeskim:mentions | umls-concept:C0008653 | lld:lifeskim |
| pubmed-article:7692269 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:7692269 | lifeskim:mentions | umls-concept:C0678226 | lld:lifeskim |
| pubmed-article:7692269 | lifeskim:mentions | umls-concept:C1979975 | lld:lifeskim |
| pubmed-article:7692269 | lifeskim:mentions | umls-concept:C1705181 | lld:lifeskim |
| pubmed-article:7692269 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:7692269 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:7692269 | lifeskim:mentions | umls-concept:C1704666 | lld:lifeskim |
| pubmed-article:7692269 | lifeskim:mentions | umls-concept:C1517892 | lld:lifeskim |
| pubmed-article:7692269 | lifeskim:mentions | umls-concept:C1705242 | lld:lifeskim |
| pubmed-article:7692269 | lifeskim:mentions | umls-concept:C0208973 | lld:lifeskim |
| pubmed-article:7692269 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7692269 | pubmed:dateCreated | 1993-11-5 | lld:pubmed |
| pubmed-article:7692269 | pubmed:abstractText | Defects in loci on chromosome 11 have been associated with tumourigenicity, anchorage-independent growth, metastasis and radiosensitive DNA repair in tumour cells. The introduction of normal chromosome 11 into these cells suppresses these responses. In the present study we tested two hypotheses: (1) that microcell fusion of normal chromosome 11 into bladder-carcinoma cells (A1698) can protect the cells against chromosomal damage by oxidative stress; and (2) that insertion of normal chromosome 11 corrects a single-strand (SS) DNA-repair defect. Cultures of A1698 (termed parent) and its microcell-mediated hybrid (termed hybrid) were exposed for 1 h to xanthine/xanthine oxidase (X/XO) or co-incubated with human neutrophils activated with 12-O-tetradecanoyl-phorbol-13-acetate (TPA). Micronucleus frequencies (an indication of chromosomal damage) were significantly higher in parent cultures after treatment than in hybrid (P < 0.0001). The level of single-strand DNA breakage and its repair was assayed in X/XO-treated cultures with the alkaline comet assay. There was no significant difference between parent and hybrid in the amount of SS DNA breakage at treatment (P > 0.1) or after 20 min of repair (P > 0.1). The data support the involvement of a defect in chromosome 11 leading to sensitivity to oxidative stress and suggest this defect is not in the initial amount or rate of rejoining of SS DNA breakage. | lld:pubmed |
| pubmed-article:7692269 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7692269 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7692269 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7692269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7692269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7692269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7692269 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7692269 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7692269 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7692269 | pubmed:issn | 0027-5107 | lld:pubmed |
| pubmed-article:7692269 | pubmed:author | pubmed-author:WardA JAJ | lld:pubmed |
| pubmed-article:7692269 | pubmed:author | pubmed-author:RosinM PMP | lld:pubmed |
| pubmed-article:7692269 | pubmed:author | pubmed-author:OliveP LPL | lld:pubmed |
| pubmed-article:7692269 | pubmed:author | pubmed-author:BurrA HAH | lld:pubmed |
| pubmed-article:7692269 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7692269 | pubmed:volume | 294 | lld:pubmed |
| pubmed-article:7692269 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7692269 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7692269 | pubmed:pagination | 299-308 | lld:pubmed |
| pubmed-article:7692269 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:7692269 | pubmed:meshHeading | pubmed-meshheading:7692269-... | lld:pubmed |
| pubmed-article:7692269 | pubmed:meshHeading | pubmed-meshheading:7692269-... | lld:pubmed |
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| pubmed-article:7692269 | pubmed:meshHeading | pubmed-meshheading:7692269-... | lld:pubmed |
| pubmed-article:7692269 | pubmed:meshHeading | pubmed-meshheading:7692269-... | lld:pubmed |
| pubmed-article:7692269 | pubmed:meshHeading | pubmed-meshheading:7692269-... | lld:pubmed |
| pubmed-article:7692269 | pubmed:meshHeading | pubmed-meshheading:7692269-... | lld:pubmed |
| pubmed-article:7692269 | pubmed:meshHeading | pubmed-meshheading:7692269-... | lld:pubmed |
| pubmed-article:7692269 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7692269 | pubmed:articleTitle | A sensitivity to oxidative stress is linked to chromosome 11 but is not due to a difference in single strand DNA breakage or repair. | lld:pubmed |
| pubmed-article:7692269 | pubmed:affiliation | British Columbia Cancer Research Centre, Vancouver, Canada. | lld:pubmed |
| pubmed-article:7692269 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7692269 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7692269 | lld:pubmed |
