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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0004096,
umls-concept:C0007634,
umls-concept:C0019588,
umls-concept:C0023545,
umls-concept:C0024264,
umls-concept:C0027950,
umls-concept:C0030685,
umls-concept:C0030705,
umls-concept:C0205269,
umls-concept:C0391871,
umls-concept:C0392747,
umls-concept:C0443172,
umls-concept:C0680255,
umls-concept:C0682545,
umls-concept:C1283071,
umls-concept:C1709707,
umls-concept:C1963578
|
| pubmed:issue |
2
|
| pubmed:dateCreated |
1993-7-14
|
| pubmed:abstractText |
The proportion of inflammatory cells in bronchoalveolar lavage (BAL) fluid and the release of chemical mediators from BAL and peripheral blood cells were examined in 40 patients with steroid-dependent intractable asthma (SDIA) to clarify the effects of a long-term glucocorticoid regimen on these cells. The proportion of BAL lymphocytes was significantly reduced (p < 0.01) and the proportion of BAL neutrophils was significantly increased (p < 0.01) in SDIA patients compared with non-SDIA patients. The proportion of basophilic cells (mast cells and basophils) in BAL fluid was significantly lower in SDIA patients compared to non-SDIA patients (p < 0.02). The values of six ventilatory parameters were significantly lower in SDIA patients with a high proportion of BAL neutrophils (more than 10%) compared with the values in non-SDIA patients. The release of histamine and leukotriene C4 (LTC4) from the BAL cells of patients with atopic asthma was significantly reduced in SDIA patients compared with non-SDIA patients (p < 0.05). These results show that the changes in the proportion of BAL cells are observed in patients with SDIA, and these changes are related to suppressed ventilatory function and a reduction in the release of histamine and LTC4 from BAL cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1018-2438
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
101
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
196-202
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7685219-Adult,
pubmed-meshheading:7685219-Aged,
pubmed-meshheading:7685219-Asthma,
pubmed-meshheading:7685219-Basophils,
pubmed-meshheading:7685219-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:7685219-Chronic Disease,
pubmed-meshheading:7685219-Female,
pubmed-meshheading:7685219-Histamine Release,
pubmed-meshheading:7685219-Humans,
pubmed-meshheading:7685219-Leukocyte Count,
pubmed-meshheading:7685219-Leukotriene B4,
pubmed-meshheading:7685219-Leukotrienes,
pubmed-meshheading:7685219-Lymphocytes,
pubmed-meshheading:7685219-Male,
pubmed-meshheading:7685219-Middle Aged,
pubmed-meshheading:7685219-Neutrophils,
pubmed-meshheading:7685219-Prednisolone,
pubmed-meshheading:7685219-Respiratory Function Tests,
pubmed-meshheading:7685219-SRS-A
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Changes in the proportions of bronchoalveolar lymphocytes, neutrophils and basophilic cells and the release of histamine and leukotrienes from bronchoalveolar cells in patients with steroid-dependent intractable asthma.
|
| pubmed:affiliation |
Department of Medicine, Okayama University Medical School, Tottori, Japan.
|
| pubmed:publicationType |
Journal Article
|