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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6416
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pubmed:dateCreated |
1993-4-13
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pubmed:abstractText |
A complementary DNA encoding an inward rectifier K+ channel (IRK1) was isolated from a mouse macrophage cell line by expression cloning. This channel conducts inward K+ current below the K+ equilibrium potential but passes little outward K+ current. The IRK1 channel contains only two putative transmembrane segments per subunit and corresponds to the inner core structure of voltage-gated K+ channels. The IRK1 channel and an ATP-regulated K+ channel show extensive sequence similarity and constitute a new superfamily.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
362
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pubmed:geneSymbol |
IRK1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
127-33
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7680768-Amino Acid Sequence,
pubmed-meshheading:7680768-Animals,
pubmed-meshheading:7680768-Base Sequence,
pubmed-meshheading:7680768-Cattle,
pubmed-meshheading:7680768-Cell Line,
pubmed-meshheading:7680768-Cloning, Molecular,
pubmed-meshheading:7680768-DNA,
pubmed-meshheading:7680768-Gene Library,
pubmed-meshheading:7680768-Guinea Pigs,
pubmed-meshheading:7680768-Macrophages,
pubmed-meshheading:7680768-Membrane Proteins,
pubmed-meshheading:7680768-Mice,
pubmed-meshheading:7680768-Models, Structural,
pubmed-meshheading:7680768-Molecular Sequence Data,
pubmed-meshheading:7680768-Multigene Family,
pubmed-meshheading:7680768-Oocytes,
pubmed-meshheading:7680768-Poly A,
pubmed-meshheading:7680768-Potassium Channels,
pubmed-meshheading:7680768-Potassium Channels, Inwardly Rectifying,
pubmed-meshheading:7680768-RNA,
pubmed-meshheading:7680768-RNA, Messenger,
pubmed-meshheading:7680768-Rats,
pubmed-meshheading:7680768-Recombinant Proteins,
pubmed-meshheading:7680768-Sequence Homology, Amino Acid,
pubmed-meshheading:7680768-Xenopus
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pubmed:year |
1993
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pubmed:articleTitle |
Primary structure and functional expression of a mouse inward rectifier potassium channel.
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pubmed:affiliation |
Howard Hughes Medical Institute, University of California, San Francisco 94143-0724.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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