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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1993-3-12
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pubmed:abstractText |
We have evaluated the cross-reactivity characteristics of two distinct immunometric assays for the measurement of free beta-human chorionic gonadotropin (free beta). These maternal serum assays have been used in the initial studies which evaluated free beta as a marker in the prenatal detection of Down's syndrome. It has been suggested that free beta assays are subject to substantial potential for cross-reactivity. To confirm that free beta was the analyte responsible for enhanced detection efficiency both non-competitive and competitive cross-reactivity evaluations were undertaken. These studies demonstrated acceptably small cross-reactivity to other glycoprotein hormones or their beta components. We conclude that properly designed free beta assays will provide specific analyte measurement and improved detection efficiency in Down's syndrome screening.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0004-5632
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30 ( Pt 1)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
94-8
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7679563-Antibodies, Monoclonal,
pubmed-meshheading:7679563-Biological Markers,
pubmed-meshheading:7679563-Chorionic Gonadotropin,
pubmed-meshheading:7679563-Chorionic Gonadotropin, beta Subunit, Human,
pubmed-meshheading:7679563-Cross Reactions,
pubmed-meshheading:7679563-Down Syndrome,
pubmed-meshheading:7679563-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:7679563-Female,
pubmed-meshheading:7679563-Humans,
pubmed-meshheading:7679563-Molecular Weight,
pubmed-meshheading:7679563-Peptide Fragments,
pubmed-meshheading:7679563-Pregnancy,
pubmed-meshheading:7679563-Prenatal Diagnosis
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pubmed:year |
1993
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pubmed:articleTitle |
Free beta-chorionic gonadotropin: a cross-reactivity study of two immunometric assays used in prenatal maternal serum screening for Down's syndrome.
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pubmed:affiliation |
Research Division, NTD Laboratories Inc., New York 11514.
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pubmed:publicationType |
Journal Article
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