Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1993-3-8
|
| pubmed:abstractText |
We examined the expression of the transglutaminase 1 (TGase 1) gene in frozen sections of normal and psoriatic epidermis by means of non-radioactive in situ hybridization with digoxigenin-labelled cRNA probes. TGase 1 mRNA was expressed in the granular layer of normal epidermis, regardless of ortho- or hyperkeratosis. However, in psoriatic epidermis, TGase 1 mRNA was detected in the suprabasal spinous layer, but not in the subcorneal layer. These results indicate that TGase 1 gene expression is limited to the last stage of keratinization in normal epidermis and this regulation is disturbed in psoriasis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0007-0963
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
128
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
23-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7678985-Adult,
pubmed-meshheading:7678985-Cell Differentiation,
pubmed-meshheading:7678985-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:7678985-Humans,
pubmed-meshheading:7678985-In Situ Hybridization,
pubmed-meshheading:7678985-Keratins,
pubmed-meshheading:7678985-Male,
pubmed-meshheading:7678985-Psoriasis,
pubmed-meshheading:7678985-RNA, Messenger,
pubmed-meshheading:7678985-Skin,
pubmed-meshheading:7678985-Transglutaminases
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Localization of transglutaminase 1 mRNA in normal and psoriatic epidermis by non-radioactive in situ hybridization.
|
| pubmed:affiliation |
Department of Dermatology, Kyoto Prefectural University of Medicine, Japan.
|
| pubmed:publicationType |
Journal Article
|