Linked Life Data

7667208

Source:http://linkedlifedata.com/resource/pubmed/id/7667208

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-10-10
pubmed:abstractText
Liver tissue from 14 female patients with primary biliary cirrhosis (PBC; stages I-IV) was systematically investigated for the prevalence and distribution of dendritic antigen-presenting cells. Dendritic cells (DCs) were immunhistochemically identified by use of anti-S 100 protein and KiMlp antibodies. We confirm previous findings that, in early PBC, S 100 protein-positive DCs can be detected within the lining of bile duct epithelia. However, the present study disclosed that S 100 protein- and KiMlp-positive DCs regularly occur in piece-meal necroses (PMNs) developing in PBC-associated chronic hepatitis. DCs in PMNs were observed in all PBC stages, but were most prominent in late-stage PBC. These findings suggest that autoimmune tissue damage in PBC may not be limited to bile ducts, but may also ensue in hepatic parenchyma, producing the pattern of chronic hepatitis with signs of activity.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0172-8113
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
262-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
[Primary biliary cirrhosis. Localization of antigen-presenting cells in piecemeal necroses].
pubmed:affiliation
Pathologisches Institut, Universität, Bern.
pubmed:publicationType
Journal Article, English Abstract