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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6543
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pubmed:dateCreated |
1995-9-27
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pubmed:abstractText |
The product of the c-abl gene is a non-receptor tyrosine kinase that is localized to the nucleus and cytoplasm. The precise function of c-Abl is unknown. Here we show that ionizing radiation activates c-Abl. Similar results were obtained with the alkylating agents cis-platinum and mitomycin C. We also demonstrate that cells deficient in c-Abl fail to activate Jun kinase (JNK/SAP kinase) after ionizing radiation or alkylating agent exposure and that reconstitution of c-Abl in these cells restores that response. In contrast, the stress response to tumour-necrosis factor is stimulated by a c-Abl-independent mechanism. These findings indicate that c-abl is involved in the stress response to DNA-damaging agents.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cisplatin,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 4,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitomycins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-abl,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-jun
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
376
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pubmed:geneSymbol |
c-abl
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
785-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7651539-3T3 Cells,
pubmed-meshheading:7651539-Amino Acid Sequence,
pubmed-meshheading:7651539-Animals,
pubmed-meshheading:7651539-Cell Line,
pubmed-meshheading:7651539-Cisplatin,
pubmed-meshheading:7651539-DNA,
pubmed-meshheading:7651539-DNA Damage,
pubmed-meshheading:7651539-Enzyme Activation,
pubmed-meshheading:7651539-Humans,
pubmed-meshheading:7651539-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:7651539-MAP Kinase Kinase 4,
pubmed-meshheading:7651539-Mice,
pubmed-meshheading:7651539-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:7651539-Mitomycins,
pubmed-meshheading:7651539-Molecular Sequence Data,
pubmed-meshheading:7651539-Peptides,
pubmed-meshheading:7651539-Protein Kinases,
pubmed-meshheading:7651539-Protein-Tyrosine Kinases,
pubmed-meshheading:7651539-Proto-Oncogene Proteins c-abl,
pubmed-meshheading:7651539-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:7651539-Radiation, Ionizing
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pubmed:year |
1995
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pubmed:articleTitle |
Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents.
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pubmed:affiliation |
Division of Cancer Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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