Linked Life Data

7651125

Source:http://linkedlifedata.com/resource/pubmed/id/7651125

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1995-9-25
pubmed:abstractText
The authors present a high field in vivo demonstration of our 2-dimensional calibration methods for determining magnesium ion concentration ([Mg]), under conditions of fluctuating pH, from the three 31P NMR chemical shift differences of ATP. The effect of 3 h of hypoxic-ischemic insult (HI) on intracellular brain [Mg] was evaluated by using a well established 7-day-old rat model of cerebral HI. During the final hour of HI, there was a significant increase (P < 0.001) in free magnesium as well as in the ratio of total [Mg]/[ATP]. The normal, HI, and early (1-2 h) recovery values of free [Mg] were 0.336 +/- 0.015, 0.519 +/- 0.104, and 0.337 +/- 0.071 mM, respectively. These results are consistent with the temporal changes in [ATP]. Our assessment of [Mg] and pH for this high error measurement is general for most in vivo applications and may be routinely implemented.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0740-3194
pubmed:author
pubmed:issnType
Print
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
853-7
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Application of the accurate assessment of intracellular magnesium and pH from the 31P shifts of ATP to cerebral hypoxia-ischemia in neonatal rat.
pubmed:affiliation
Department of Radiology, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey 17033, USA.
pubmed:publicationType
Journal Article