Linked Life Data

7640851

Source:http://linkedlifedata.com/resource/pubmed/id/7640851

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-9-20
pubmed:abstractText
The effect of allopurinol (50 mg/kg) on the rate of full thickness excisional wound contraction in the Hooded Lister rat was assessed by planimetric and histological examinations. Compared with control animals, those treated with allopurinol showed a significantly lower coefficient of wound area contraction for days 0-7 (p < 0.05) than those of control animals. Histologically, in the allopurinol treated wounds the granulation tissue was less cellular but appeared to contain more collagen. This inhibition by allopurinol of the contraction phase of wound healing associated with an increased quantity of granulation tissue suggests that mediation of the process may involve a complex interaction between the fibroblasts/myofibroblasts and free radicals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0007-1226
pubmed:author
pubmed:issnType
Print
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
198-202
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Modifications to the rate of wound contraction by allopurinol.
pubmed:affiliation
Department of Biomedical Sciences, University of Bradford, UK.
pubmed:publicationType
Journal Article