rdf:type |
|
lifeskim:mentions |
umls-concept:C0006118,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0017638,
umls-concept:C0033684,
umls-concept:C0070140,
umls-concept:C0086418,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C1171362,
umls-concept:C1515670,
umls-concept:C1552599,
umls-concept:C1704787
|
pubmed:issue |
1
|
pubmed:dateCreated |
1995-8-14
|
pubmed:databankReference |
|
pubmed:abstractText |
We report the cloning of a cDNA encoding GliPR (glioma pathogenesis-related protein), a protein that is structurally similar to plant pathogenesis-related proteins. The GLIPR gene is highly expressed in the human brain tumor, glioblastoma multiforme/astrocytoma, but neither in normal fetal or adult brain tissue, nor in other nervous system tumors. GliPR shares up to 50% amino acid (aa) homology with plant pathogenesis-related proteins, group 1, over a region that comprises almost two thirds of the protein. We speculate that there may be functional similarities between the human and plant proteins as well.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/pathogenesis-related proteins, plant
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0378-1119
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
14
|
pubmed:volume |
159
|
pubmed:geneSymbol |
GLIPR
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
131-5
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:7607567-Amino Acid Sequence,
pubmed-meshheading:7607567-Astrocytoma,
pubmed-meshheading:7607567-Base Sequence,
pubmed-meshheading:7607567-Brain Neoplasms,
pubmed-meshheading:7607567-Cloning, Molecular,
pubmed-meshheading:7607567-DNA, Complementary,
pubmed-meshheading:7607567-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:7607567-Glioblastoma,
pubmed-meshheading:7607567-Humans,
pubmed-meshheading:7607567-Molecular Sequence Data,
pubmed-meshheading:7607567-Neoplasm Proteins,
pubmed-meshheading:7607567-Nerve Tissue Proteins,
pubmed-meshheading:7607567-Plant Proteins,
pubmed-meshheading:7607567-RNA, Messenger,
pubmed-meshheading:7607567-RNA, Neoplasm,
pubmed-meshheading:7607567-Sequence Alignment,
pubmed-meshheading:7607567-Sequence Analysis, DNA,
pubmed-meshheading:7607567-Sequence Homology, Amino Acid,
pubmed-meshheading:7607567-Tumor Cells, Cultured
|
pubmed:year |
1995
|
pubmed:articleTitle |
The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors.
|
pubmed:affiliation |
Department of Neurologic Surgery, University of California, San Francisco 94143, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|