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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
14
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pubmed:dateCreated |
1995-8-10
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pubmed:databankReference |
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pubmed:abstractText |
The glass gene is required for proper photo-receptor differentiation during development of the Drosophila eye glass codes for a DNA-binding protein containing five zinc fingers that we show is a transcriptional activator. A comparison of the sequences of the glass genes from two species of Drosophila and a detailed functional domain analysis of the Drosophila melanogaster glass gene reveal that both the DNA-binding domain and the transcriptional-activation domain are highly conserved between the two species. Analysis of the DNA-binding domain of glass indicates that the three carboxyl-terminal zinc fingers alone are necessary and sufficient for DNA binding. We also show that a deletion mutant of glass containing only the DNA-binding domain can behave in a dominant-negative manner both in vivo and in a cell culture assay that measures transcriptional activation.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-1324404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-1372244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-1398072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-1497306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-1516835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-1569931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-1846049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-1974051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-1974228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-2010085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-2115169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-2770860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-2843425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-2881781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-3108854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-3142690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-3208754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-6442354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-7925015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-7926727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-8187644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-8248145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-8278363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7604032-8330738
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6557-61
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7604032-Amino Acid Sequence,
pubmed-meshheading:7604032-Animals,
pubmed-meshheading:7604032-Base Sequence,
pubmed-meshheading:7604032-Binding Sites,
pubmed-meshheading:7604032-Cell Line,
pubmed-meshheading:7604032-Chloramphenicol O-Acetyltransferase,
pubmed-meshheading:7604032-DNA,
pubmed-meshheading:7604032-DNA-Binding Proteins,
pubmed-meshheading:7604032-Drosophila,
pubmed-meshheading:7604032-Drosophila Proteins,
pubmed-meshheading:7604032-Drosophila melanogaster,
pubmed-meshheading:7604032-Eye,
pubmed-meshheading:7604032-Gene Expression,
pubmed-meshheading:7604032-Genes, Insect,
pubmed-meshheading:7604032-Microscopy, Electron, Scanning,
pubmed-meshheading:7604032-Molecular Sequence Data,
pubmed-meshheading:7604032-Oligodeoxyribonucleotides,
pubmed-meshheading:7604032-Sequence Homology, Amino Acid,
pubmed-meshheading:7604032-Trans-Activators,
pubmed-meshheading:7604032-Transcription, Genetic,
pubmed-meshheading:7604032-Transcription Factors,
pubmed-meshheading:7604032-Transfection,
pubmed-meshheading:7604032-Zinc Fingers
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pubmed:year |
1995
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pubmed:articleTitle |
Functional domain analysis of glass, a zinc-finger-containing transcription factor in Drosophila.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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