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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1995-11-29
|
| pubmed:abstractText |
The impact of microalbuminuria and macroalbuminuria on mortality was evaluated prospectively in 328 Caucasian patients with non-insulin-dependent diabetes mellitus (NIDDM) followed for 5 years. One hundred ninety-one (109 men and 82 women) patients with normoalbuminuria (albumin excretion rate [AER] < 30 mg/24 h), 86 (50 men and 36 women) patients with microalbuminuria (AER 30-299 mg/24 h), and 51 (43 men and 8 women) patients with macroalbuminuria (AER > or = 300 mg/24 h) < 66 years old at entry were followed from 1987 until death or until 1 January 1993. Mean age at entry was 54 (SD 9) years. In January 1993, 8% of patients with normoalbuminuria, 20% of patients with microalbuminuria, and 35% of patients with macroalbuminuria had died (predominantly from cardiovascular disease) (P < 0.01 [normoalbuminuria versus micro- and macroalbuminuria] and P < 0.05 [microalbuminuria versus macroalbuminuria]). Cox multiple regression analysis revealed significant predictors of all-cause mortality to be preexisting coronary heart disease (relative risk [95% confidence interval]), 2.9 (1.6-5.1); log10AER (factor 10), 1.9 (1.4-2.6); HbA1c level (%), 1.2 (1.0-1.4); and age (years), 1.08 (1.03-1.13). Significant predictors of cardiovascular mortality included preexisting coronary heart disease, 6.1 (2.8-13.5); macroalbuminuria, 2.5 (1.1-5.8); HbA1c level (%), 1.3 (1.1-1.6); and systolic blood pressure (10 mmHg), 1.2 (1.0-1.4). Univariate Cox survival analysis in the normoalbuminuric group revealed that AER above the median of 8 mg/24 h was associated with an increased all-cause mortality risk of 2.7 (0.93-7.69) (P = 0.07).(ABSTRACT TRUNCATED AT 250 WORDS)
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobin A, Glycosylated
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0012-1797
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
44
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1303-9
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7589828-Aged,
pubmed-meshheading:7589828-Albuminuria,
pubmed-meshheading:7589828-Biological Markers,
pubmed-meshheading:7589828-Blood Glucose,
pubmed-meshheading:7589828-Cholesterol,
pubmed-meshheading:7589828-Cholesterol, HDL,
pubmed-meshheading:7589828-Cohort Studies,
pubmed-meshheading:7589828-Diabetes Mellitus, Type 2,
pubmed-meshheading:7589828-Diabetic Retinopathy,
pubmed-meshheading:7589828-Female,
pubmed-meshheading:7589828-Hemoglobin A, Glycosylated,
pubmed-meshheading:7589828-Humans,
pubmed-meshheading:7589828-Male,
pubmed-meshheading:7589828-Middle Aged,
pubmed-meshheading:7589828-Predictive Value of Tests,
pubmed-meshheading:7589828-Reference Values,
pubmed-meshheading:7589828-Risk Factors,
pubmed-meshheading:7589828-Survival Rate,
pubmed-meshheading:7589828-Time Factors
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Albuminuria and poor glycemic control predict mortality in NIDDM.
|
| pubmed:affiliation |
Steno Diabetes Center, Gentofte, Denmark.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|